ID   UW228
AC   CVCL_8585
SY   UW 228; HBT 228; HBT228
DR   cancercelllines; CVCL_8585
DR   Cell_Model_Passport; SIDM01399
DR   DepMap; ACH-001232
DR   GEO; GSM919366
DR   IARC_TP53; 26932
DR   Progenetix; CVCL_8585
DR   Wikidata; Q54992372
RX   DOI=10.1007/0-306-46861-1_11;
RX   PubMed=10667577;
RX   PubMed=11023825;
RX   PubMed=18505928;
RX   PubMed=20847082;
RX   PubMed=21177782;
RX   PubMed=24297863;
RX   PubMed=27498314;
RX   PubMed=27812533;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Unspecified (PubMed=18505928; DepMap=ACH-001232).
CC   Omics: Deep exome analysis.
CC   Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
DI   NCIt; C129442; Medulloblastoma, SHH-activated, TP53-mutant
DI   ORDO; Orphanet_616; Medulloblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_DH81 ! UW402
OI   CVCL_DH82 ! UW426
SX   Female
AG   9Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
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RX   DOI=10.1007/0-306-46861-1_11;
RA   Ali-Osman F.;
RT   "Brain tumors.";
RL   (In) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=10667577;
RA   Srivenugopal K.S., Mullapudi S.R.S., Shou J., Hazra T.K., Ali-Osman F.;
RT   "Protein phosphorylation is a regulatory mechanism for
RT   O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.";
RL   Cancer Res. 60:282-287(2000).
//
RX   PubMed=11023825; DOI=10.1042/bj3510393;
RA   Mullapudi S.R.S., Ali-Osman F., Shou J., Srivenugopal K.S.;
RT   "DNA repair protein O6-alkylguanine-DNA alkyltransferase is
RT   phosphorylated by two distinct and novel protein kinases in human
RT   brain tumour cells.";
RL   Biochem. J. 351:393-402(2000).
//
RX   PubMed=18505928; DOI=10.1158/1541-7786.MCR-07-2105;
RA   Lo H.-W., Stephenson L., Cao X.-Y., Milas M., Pollock R.E., Ali-Osman F.;
RT   "Identification and functional characterization of the human
RT   glutathione S-transferase P1 gene as a novel transcriptional target of
RT   the p53 tumor suppressor gene.";
RL   Mol. Cancer Res. 6:843-850(2008).
//
RX   PubMed=20847082; DOI=10.1093/neuonc/noq091;
RA   Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F.,
RA   Marquez V.E., Cho Y.-J., Pomeroy S.L.;
RT   "Neuralized1 causes apoptosis and downregulates Notch target genes in
RT   medulloblastoma.";
RL   Neuro-oncol. 12:1244-1256(2010).
//
RX   PubMed=21177782; DOI=10.1093/neuonc/noq179;
RA   Weeraratne S.D., Amani V.M., Neiss A., Teider N., Scott D.K.,
RA   Pomeroy S.L., Cho Y.-J.;
RT   "miR-34a confers chemosensitivity through modulation of MAGE-A and p53
RT   in medulloblastoma.";
RL   Neuro-oncol. 13:165-175(2011).
//
RX   PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281;
RA   Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S.,
RA   Tang Y.-J., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F.-R.,
RA   Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J.,
RA   Liu K.-W., Wechsler-Reya R.J., Weiss W.A., Swartling F.J., Kieran M.W.,
RA   Bradner J.E., Beroukhim R., Cho Y.-J.;
RT   "BET bromodomain inhibition of MYC-amplified medulloblastoma.";
RL   Clin. Cancer Res. 20:912-925(2014).
//
RX   PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028;
RA   Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.;
RT   "In vitro models of medulloblastoma: choosing the right tool for the
RT   job.";
RL   J. Biotechnol. 236:10-25(2016).
//
RX   PubMed=27812533; DOI=10.1016/j.dib.2016.10.004;
RA   Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.;
RT   "Data on the number and frequency of scientific literature citations
RT   for established medulloblastoma cell lines.";
RL   Data Brief 9:696-698(2016).
//