ID   RM10
AC   CVCL_8463
SY   RM-10
DR   BioSample; SAMN03151811
DR   Wikidata; Q54950638
RX   PubMed=2167410;
RX   PubMed=10071072;
RX   PubMed=10516762;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=10516762; PubMed=12592342; PubMed=20143388). Originally thought to originate from the bone marrow of a 44 year old female patient with chronic myelogenous leukemia.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00262.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=10516762; DOI=10.1038/sj.leu.2401510;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   MacLeod, Roderick A.F.
RT   "False human hematopoietic cell lines: cross-contaminations and
RT   misinterpretations.";
RL   Leukemia 13:1601-1607(1999).
//
RX   PubMed=2167410;
RA   Hirata, Jouji
RA   Sato, Hiroyuki
RA   Takahira, Hiroyuki
RA   Shiokawa, Satoshi
RA   Endo, Toshiyasu
RA   Nishimura, Junji
RA   Katsuno, Makoto
RA   Masuda, Seiji
RA   Sasaki, Ryoko
RA   Fukumaki, Yasuyuki
RA   Namata, Hajime
RA   Okano, Hiromitsu
RT   "A novel CD10-positive erythroid cell line, RM10, established from a
RT   patient with chronic myelogenous leukemia.";
RL   Leukemia 4:365-372(1990).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   MacLeod, Roderick A.F.
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//