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Cellosaurus NK-YS (CVCL_8461)

[Text version]
Cell line name NK-YS
Synonyms NKYS
Accession CVCL_8461
Secondary accession CVCL_AX40
Resource Identification Initiative To cite this cell line use: NK-YS (RRID:CVCL_8461)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: ~48 hours (PubMed=9694726).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: CNV analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: NK T-cell; CL=CL_0000814.
Disease Nasal type extranodal NK/T-cell lymphoma (NCIt: C4684)
Extranodal nasal NK/T cell lymphoma (ORDO: Orphanet_86879)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=9694726; DOI=10.1182/blood.V92.4.1374
Tsuchiyama J., Yoshino T., Mori M., Kondoh E., Oka T., Akagi T., Hiraki A., Nakayama H., Shibuya A., Ma Y.-X., Kawabata T., Okada S., Harada M.
Characterization of a novel human natural killer-cell line (NK-YS) established from natural killer cell lymphoma/leukemia associated with Epstein-Barr virus infection.
Blood 92:1374-1383(1998)

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=19194464; DOI=10.1038/leu.2009.3
Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H.-M., Klinkebiel D.L., Christman J.K., Patel K.N., Cao K., Shen L., Dybkaer K., Tsui I.F.L., Ali H.H., Shimizu N., Au W.Y., Lam W.L., Chan W.-C.
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.-Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K.E., Vose J.M., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H., Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.-C.
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911
Kucuk C., Jiang B., Hu X.-Z., Zhang W.-Y., Chan J.K.C., Xiao W.-M., Lack N., Alkan C., Williams J.C., Avery K.N., Kavak P., Scuto A., Sen E., Gaulard P., Staudt L.M., Iqbal J., Zhang W.-W., Cornish A., Gong Q., Yang Q.-P., Sun H., d'Amore F.A., Leppa S., Liu W.-P., Fu K., de Leval L., McKeithan T.W., Chan W.-C.
Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells.
Nat. Commun. 6:6025.1-6025.12(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8461
Encyclopedic resources Wikidata; Q54930662
Gene expression databases GEO; GSM472002
GEO; GSM3021082
Polymorphism and mutation databases Cosmic; 1534872
Cosmic; 1542075
Cosmic; 2025325
Cosmic; 2390119
Cosmic; 2785205
Progenetix; CVCL_8461
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number16