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Cellosaurus HAC-2 (CVCL_8354)

[Text version]
Cell line name HAC-2
Synonyms HAC 2; Hac2
Accession CVCL_8354
Resource Identification Initiative To cite this cell line use: HAC-2 (RRID:CVCL_8354)
Comments Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: 46.8 hours (CelloPub=CLPUB00045).
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=25846456).
Disease Ovarian clear cell adenocarcinoma (NCIt: C40078)
Clear cell adenocarcinoma of the ovary (ORDO: Orphanet_398971)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO12
D5S81812,13
D7S8209,11
D13S3178,9
D16S53910,11
TH017
TPOX11
vWA14,16

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

CLPUB00045
Nishida M., Iwasaki H.
Establishment of a human ovarian clear cell carcinoma cell line (HAC-2 cells) in vitro.
Hum. Cell 1:345-346(1988)

PubMed=8980248; DOI=10.1002/(SICI)1097-0215(19961220)69:6<466::AID-IJC8>3.0.CO;2-2
Ichikawa Y., Yoshida S., Koyama Y., Hirai M., Ishikawa T., Nishida M., Tsunoda H., Kubo T., Miwa M., Uchida K.
Inactivation of p16/CDKN2 and p15/MTS2 genes in different histological types and clinical stages of primary ovarian tumors.
Int. J. Cancer 69:466-470(1996)

PubMed=25846456; DOI=10.3892/ijo.2015.2951
Takenaka M., Saito M., Iwakawa R., Yanaihara N., Saito M., Kato M., Ichikawa H., Shibata T., Yokota J., Okamoto A., Kohno T.
Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.
Int. J. Oncol. 46:2389-2398(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) JCRB; JCRB1359
JCRB; JCRB1539
JCRB; NIHS0567 - Discontinued
Cell line databases/resources cancercelllines; CVCL_8354
Encyclopedic resources Wikidata; Q54872301
Polymorphism and mutation databases Cosmic; 877480
Cosmic; 931363
Cosmic; 945375
Cosmic; 1152560
Cosmic; 2582795
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21