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Cellosaurus ATL-35T (CVCL_8339)

[Text version]
Cell line name ATL-35T
Synonyms ATL-35T(-); ATL35T
Accession CVCL_8339
Resource Identification Initiative To cite this cell line use: ATL-35T (RRID:CVCL_8339)
Comments Population: Japanese.
Characteristics: Lost its original IL2 dependency.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Donor information: Established from a patient suffering from adult T-cell leukemia/lymphoma (ATLL).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=16242045; DOI=10.1186/1742-4690-2-64; PMCID=PMC1289293
Taniguchi Y., Nosaka K., Yasunaga J.-i., Maeda M., Mueller N., Okayama A., Matsuoka M.
Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms.
Retrovirology 2:64.1-64.16(2005)

PubMed=16314839; DOI=10.1038/sj.onc.1209256
Ahsan M.K., Masutani H., Yamaguchi Y., Kim Y.-C., Nosaka K., Matsuoka M., Nishinaka Y., Maeda M., Yodoi J.
Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.
Oncogene 25:2181-2191(2006)

PubMed=32210945; DOI=10.3389/fmicb.2020.00356; PMCID=PMC7067701
Maeda M., Tanabe-Shibuya J., Miyazato P., Masutani H., Yasunaga J.-i., Usami K., Shimizu A., Matsuoka M.
IL-2/IL-2 receptor pathway plays a crucial role in the growth and malignant transformation of HTLV-1-infected T cells to develop adult T-cell leukemia.
Front. Microbiol. 11:356.1-356.17(2020)

Cross-references
Cell line collections (Providers) RCB; RCB3555
Encyclopedic resources Wikidata; Q54751262
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14