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Cellosaurus J-Lat 9.2 (CVCL_8285)

[Text version]
Cell line name J-Lat 9.2
Synonyms J-Lat clone 9.2; J-Lat full length clone 9.2
Accession CVCL_8285
Resource Identification Initiative To cite this cell line use: J-Lat 9.2 (RRID:CVCL_8285)
Comments Population: Caucasian.
Virology: Latently infected with HIV-1 strain R7/E-/GFP. The integrated HIV-1 genome is located in PP5 4th intron (PubMed=18692772; PubMed=26912621; PubMed=28086908).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479
Jordan A., Bisgrove D., Verdin E.
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.
EMBO J. 22:1868-1877(2003)

PubMed=18692772; DOI=10.1016/j.chom.2008.05.016; PMCID=PMC4217705
Lenasi T., Contreras X., Peterlin B.M.
Transcriptional interference antagonizes proviral gene expression to promote HIV latency.
Cell Host Microbe 4:123-133(2008)

PubMed=26912621; DOI=10.1128/JVI.01617-15; PMCID=PMC4836361
Sunshine S., Kirchner R., Amr S.S., Mansur L., Shakhbatyan R., Kim M., Bosque A., Siliciano R.F., Planelles V., Hofmann O., Sui S.H., Li J.Z.
HIV integration site analysis of cellular models of HIV latency with a probe-enriched next-generation sequencing assay.
J. Virol. 90:4511-4519(2016)

PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U.
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-9848
Cell line databases/resources cancercelllines; CVCL_8285
Encyclopedic resources Wikidata; Q54898419
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number25