Cell line name |
J-Lat 8.4 |
Synonyms |
J-Lat clone 8.4; J-Lat full length clone 8.4 |
Accession |
CVCL_8284 |
Resource Identification Initiative |
To cite this cell line use: J-Lat 8.4 (RRID:CVCL_8284) |
Comments |
Population: Caucasian. Virology: Latently infected with HIV-1 strain R7/E-/GFP. The integrated HIV-1 genome is located in FUBP1 (PubMed=28086908). Transfected with: UniProtKB; P42212; GFP. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
Publications | PubMed=12682019; DOI=10.1093/emboj/cdg188 Jordan A., Bisgrove D., Verdin E. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 22:1868-1877(2003) PubMed=18692772; DOI=10.1016/j.chom.2008.05.016 Lenasi T., Contreras X., Peterlin B.M. Transcriptional interference antagonizes proviral gene expression to promote HIV latency. Cell Host Microbe 4:123-133(2008) PubMed=28086908; DOI=10.1186/s12977-016-0325-2 Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U. HIV integration sites in latently infected cell lines: evidence of ongoing replication. Retrovirology 14:2.1-2.11(2017) |
Cross-references |
Cell line collections (Providers) |
HIVReagentProgram; ARP-9847
|
Cell line databases/resources |
cancercelllines; CVCL_8284
|
Encyclopedic resources |
Wikidata; Q54898418
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 05-Oct-2023 |
Version number | 23 |
---|