| Cell line name |
J-Lat 10.6 |
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| Synonyms |
J-Lat clone 10.6; J-Lat full length clone 10.6 |
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| Accession |
CVCL_8281 |
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| Resource Identification Initiative |
To cite this cell line use: J-Lat 10.6 (RRID:CVCL_8281) |
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| Comments |
Population: Caucasian.
Virology: Latently infected with HIV-1 strain R7/E-/GFP. The integrated HIV-1 genome is located in SEC16A 2nd intron (PubMed=28086908; PubMed=32354973).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479
Jordan A., Bisgrove D., Verdin E.
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.
EMBO J. 22:1868-1877(2003) PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U.
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017) PubMed=32354973; DOI=10.1128/mra.00179-20; PMCID=PMC7193928
Chung C.-H., Mele A.R., Allen A.G., Costello R., Dampier W., Nonnemacher M.R., Wigdahl B.
Integrated human immunodeficiency virus type 1 sequence in J-Lat 10.6.
Microbiol. Resour. Announc. 9:e00179.20.1-e00179.20.3(2020) |
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| Cross-references |
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| Cell line collections (Providers) |
BEI_Resources; ARP-9849
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| Cell line databases/resources |
cancercelllines; CVCL_8281
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| Encyclopedic resources |
Wikidata; Q54898415
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 24 |
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