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Cellosaurus IMC-3 (CVCL_8246)

[Text version]
Cell line name IMC-3
Accession CVCL_8246
Resource Identification Initiative To cite this cell line use: IMC-3 (RRID:CVCL_8246)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to originate from a male patient (from which IMC-2 and IMC-4 were also supposed to be derived) with maxillary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00215.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117912
D18S5116
D21S1127,28
FGA18,21
TH017
vWA16,19

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=1610070; DOI=10.1177/000348949210100613
Komiyama S., Matsui K., Miyazaki H., Kudoh S., Mizoguchi H., Shimizu N.
Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines.
Ann. Otol. Rhinol. Laryngol. 101:519-524(1992)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) RCB; RCB0727 - Discontinued
Biological sample resources BioSample; SAMN03151721
Encyclopedic resources Wikidata; Q54897517
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number22