ID   Hu609T
AC   CVCL_8241
SY   Hu 609T; HU 609 T
DR   cancercelllines; CVCL_8241
DR   Wikidata; Q54896704
RX   PubMed=6546195;
RX   PubMed=7262169;
RX   PubMed=8105864;
RX   PubMed=8900435;
CC   Problematic cell line: Contaminated. Parent cell line (Hu609) has been shown to be a J82 derivative.
CC   Population: Caucasian; Swedish.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Ser770Pro (c.2308T>C); ClinVar=VCV000140988; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro124Leu (c.371C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs*1 (c.635_1212del578); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; c.2107-2A>G; ClinVar=VCV000013077; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys320Asn (c.960G>C); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8240 ! Hu609
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 20
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RX   PubMed=8105864; DOI=10.1038/bjc.1993.449; PMCID=PMC1968741;
RA   Christensen, Britta
RA   Hansen, Claus
RA   Debiec-Rychter, Maria
RA   Kieler, Jorgen
RA   Ottensen, S.
RA   Schmidt, Jacqueline
RT   "Identity of tumorigenic human urothelial cell lines and
RT   'spontaneously' transformed sublines.";
RL   Br. J. Cancer 68:879-884(1993).
//
RX   PubMed=8900435; DOI=10.1002/(SICI)1097-0215(19961009)68:2<239::AID-IJC17>3.0.CO;2-5;
RA   Klopocki, Arkadiusz Grzegorz
RA   Krop-Watorek, Anna
RA   Dus, Danuta
RA   Ugorski, Maciej
RT   "Adhesion of human uroepithelial cells to E-selectin: possible
RT   involvement of sialosyl LewisA-ganglioside.";
RL   Int. J. Cancer 68:239-244(1996).
//
RX   PubMed=7262169; DOI=10.1016/0014-2964(81)90123-7;
RA   Vilien, Mogens
RA   Wolf, Hans
RA   Rasmussen, Finn
RT   "Immunological characterization of cell lines establishing from
RT   malignant and normal human urothelium.";
RL   Eur. J. Cancer 17:321-327(1981).
//
RX   PubMed=6546195; DOI=10.1007/BF00121494;
RA   Schroyens, Wilfried
RA   Mareel, Marc M.
RA   Dragonetti, Christian H.
RT   "In vitro invasiveness of human bladder cancer from cell lines and
RT   biopsy specimens.";
RL   Clin. Exp. Metastasis 1:153-162(1983).
//