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Cellosaurus HANK1 (CVCL_8226)

[Text version]
Cell line name HANK1
Synonyms HANK-1; HANK
Accession CVCL_8226
Resource Identification Initiative To cite this cell line use: HANK1 (RRID:CVCL_8226)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 3 days (PubMed=9858215).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: CNV analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Retroperitoneal lymph node; UBERON=UBERON_0035371.
Cell type: NK T-cell; CL=CL_0000814.
Disease Nasal type extranodal NK/T-cell lymphoma (NCIt: C4684)
Extranodal nasal NK/T cell lymphoma (ORDO: Orphanet_86879)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=9858215; DOI=10.1046/j.1365-2141.1998.01029.x
Kagami Y., Nakamura S., Suzuki R., Iida S., Yatabe Y., Okada Y., Kobayashi T., Tsurumi T., Seto M., Ogura M., Taguchi O., Morishima Y.
Establishment of an IL-2-dependent cell line derived from 'nasal-type' NK/T-cell lymphoma of CD2+, sCD3-, CD3epsilon+, CD56+ phenotype and associated with the Epstein-Barr virus.
Br. J. Haematol. 103:669-677(1998)

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954
Liu A., Takakuwa T., Luo W.-J., Fujita S., Aozasa K.
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=19194464; DOI=10.1038/leu.2009.3
Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H.-M., Klinkebiel D.L., Christman J.K., Patel K.N., Cao K., Shen L., Dybkaer K., Tsui I.F.L., Ali H.H., Shimizu N., Au W.Y., Lam W.L., Chan W.-C.
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.-Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K.E., Vose J.M., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H., Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.-C.
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8226
Encyclopedic resources Wikidata; Q54872411
Gene expression databases GEO; GSM471997
GEO; GSM3021081
Polymorphism and mutation databases Cosmic; 1534876
Cosmic; 1542076
Cosmic; 2025322
Progenetix; CVCL_8226
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number17