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Cellosaurus GHE (CVCL_8199)

[Text version]
Cell line name GHE
Synonyms Glioblastome Humain E
Accession CVCL_8199
Resource Identification Initiative To cite this cell line use: GHE (RRID:CVCL_8199)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from an astrocytoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00122.
Population: Caucasian; Swedish.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=18472955; DOI=10.1155/S0962935194000402; PMCID=PMC2367047
Pelloux H., Ricard J., Nissou M.-F., Renversez J.-C., Vuillez J.-P., Meunier A., Ambroise-Thomas P.
Infection with Toxoplasma gondii does not alter TNFalpha and IL-6 secretion by a human astrocytoma cell line.
Mediators Inflamm. 3:291-295(1994)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8199
Biological sample resources BioSample; SAMN03151940
Encyclopedic resources Wikidata; Q54835780
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25