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Cellosaurus G-415 (CVCL_8198)

[Text version]
Cell line name G-415
Synonyms G415
Accession CVCL_8198
Resource Identification Initiative To cite this cell line use: G-415 (RRID:CVCL_8198)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 48 hours (Note=At 30th passage) (PubMed=7429092); 30 hours (PubMed=32293552).
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (DepMap).
Disease Gallbladder carcinoma (NCIt: C3844)
Carcinoma of gallbladder and extrahepatic biliary tract (ORDO: Orphanet_56044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): DepMap; RCB; TKG

Markers:
AmelogeninX
CSF1PO12
D3S135815,17
D5S81812
D7S82011,12
D8S117912,14
D13S3178,10
D16S53912 (TKG)
9,12 (DepMap; RCB)
D18S5112,14
D21S1132.2
FGA21,24
Penta D9
Penta E12,14
TH017
TPOX11
vWA15,16 (TKG)
16 (DepMap; RCB)

Run an STR similarity search on this cell line
Publications

PubMed=7429092; DOI=10.20772/cancersci1959.71.4_574
Koyama S., Yoshioka T., Mizushima A., Kawakita I., Yamagata S., Fukutomi H., Sakita T., Kondo I., Kikuchi M.
Establishment of a cell line (G-415) from a human gallbladder carcinoma.
Gann 71:574-575(1980)

PubMed=11713577; DOI=10.3892/ijo.19.6.1099
Jiao W., Miyazaki K., Kitajima Y.
Exogenous expression of E-cadherin in gallbladder carcinoma cell line G-415 restores its cellular polarity and differentiation.
Int. J. Oncol. 19:1099-1107(2001)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., El-Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=32293552; DOI=10.1186/s40659-020-00282-7
Garcia P., Bizama C., Rosa L., Espinoza J.A., Weber H., Cerda-Infante J., Sanchez M., Montecinos V.P., Lorenzo-Bermejo J., Boekstegers F., Davila-Lopez M., Alfaro F., Leiva-Acevedo C., Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Biol. Res. 53:13.1-13.17(2020)

PubMed=32899426; DOI=10.3390/cancers12092510
Scherer D., Davila Lopez M., Goeppert B., Abrahamsson S., Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D., Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

Cross-references
Cell line collections (Providers) RCB; RCB2640
TKG; TKG 0642
Cell line databases/resources CLO; CLO_0050017
cancercelllines; CVCL_8198
Cell_Model_Passport; SIDM01807
DepMap; ACH-001850
Biological sample resources BioSample; SAMN03471927
Encyclopedic resources Wikidata; Q54835351
Polymorphism and mutation databases Cosmic; 2674060
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22