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Cellosaurus CSM14.1 (CVCL_8182)

[Text version]
Cell line name CSM14.1
Synonyms CSM 14.1
Accession CVCL_8182
Resource Identification Initiative To cite this cell line use: CSM14.1 (RRID:CVCL_8182)
Comments Characteristics: Proliferates at 33 Celsius and displays flat morphology. At 39 Celsius the cells stop dividing and some cells change from flat cells with broad processes to neuron-like morphology (CelloPub=CLPUB00032).
Characteristics: Can be differentiated in vitro into tyrosine hydroxylase (TH) and aldehyde-dehydrogenase 2-containing neurons (PubMed=12171477).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: In situ; Embryonic brain, mesencephalon; UBERON=UBERON_0009616.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Sex of cell Sex unspecified
Age at sampling 14FD
Category Conditionally immortalized cell line
Publications

CLPUB00032
Durand M.M., Chugani D.C., Mahmoudi M., Phelps M.E.
Characterization of neuron-like cell line immortalized from primary rat mesencephalon cultures.
Soc. Neurosci. Abstr. 16:40-40(1990)

PubMed=12171477; DOI=10.1046/j.1469-7580.2002.00072.x; PMCID=PMC1570893
Haas S.J.-P., Wree A.
Dopaminergic differentiation of the Nurr1-expressing immortalized mesencephalic cell line CSM14.1 in vitro.
J. Anat. 201:61-69(2002)

PubMed=17203489; DOI=10.1002/jnr.21170
Haas S.J.-P., Beckmann S., Petrov S., Andressen C., Wree A., Schmitt O.
Transplantation of immortalized mesencephalic progenitors (CSM14.1 cells) into the neonatal parkinsonian rat caudate putamen.
J. Neurosci. Res. 85:778-786(2007)

PubMed=24592386; DOI=10.1155/2014/351821; PMCID=PMC3925624
Weiss B., Haas S.J.-P., Lessner G., Mikkat S., Kreutzer M., Glocker M.O., Wree A., Schmitt O.
The proteome of the differentiating mesencephalic progenitor cell line CSM14.1 in vitro.
BioMed Res. Int. 2014:351821.1-351821.13(2014)

Cross-references
Cell line databases/resources TOKU-E; 4009
Anatomy/cell type resources BTO; BTO_0004073
Encyclopedic resources Wikidata; Q54814665
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number13