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Cellosaurus UM-UC-2 (CVCL_8155)

[Text version]
Cell line name UM-UC-2
Synonyms UM-UC2; UMUC2; UC-2; University of Michigan-Urothelial Carcinoma-2
Accession CVCL_8155
Resource Identification Initiative To cite this cell line use: UM-UC-2 (RRID:CVCL_8155)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=19375735; PubMed=20143388). Originally thought to originate from a 61 year old male patient with a ureter transitional cell carcinoma.
Part of: BLA-40 bladder carcinoma cell line panel.
Part of: UBC-40 urothelial bladder cancer cell line index.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00281.
Population: Caucasian; Swedish.
Doubling time: 22 hours (PubMed=3761468).
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=6471236; DOI=10.1016/S0022-5347(17)49883-1
Grossman H.B., Wedemeyer G., Ren L.-Q.
UM-UC-1 and UM-UC-2: characterization of two new human transitional cell carcinoma lines.
J. Urol. 132:834-837(1984)

PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1
Grossman H.B., Wedemeyer G., Ren L.-Q., Wilson G.N., Cox B.
Improved growth of human urothelial carcinoma cell cultures.
J. Urol. 136:953-959(1986)

PubMed=16469639; DOI=10.1016/S0022-5347(05)00323-X
Sabichi A.L., Keyhani A., Tanaka N., Delacerda J., Lee I.-L., Zou C.-P., Zhou J.-H., Benedict W.F., Grossman H.B.
Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.
J. Urol. 175:1133-1137(2006)

PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731
Park H.-S., Park W.S., Bondaruk J., Tanaka N., Katayama H., Lee S., Spiess P.E., Steinberg J.R., Wang Z., Katz R.L., Dinney C.P.N., Elias K.J., Lotan Y., Naeem R.C., Baggerly K., Sen S., Grossman H.B., Czerniak B.
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
J. Natl. Cancer Inst. 100:1401-1411(2008)

PubMed=19375735; DOI=10.1016/j.juro.2009.01.108; PMCID=PMC2680455
Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.
The use of short tandem repeat profiling to characterize human bladder cancer cell lines.
J. Urol. 181:2737-2748(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A., Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G., Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C., Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B., Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G., Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D., Chanock S.J., Valencia A., Real F.X.
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=26621286; DOI=10.1186/s12864-015-2227-4; PMCID=PMC4681452
Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B., Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G., Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D., Chanock S.J., Valencia A., Real F.X.
Erratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:1019.1-1019.2(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8155
Anatomy/cell type resources BTO; BTO_0006290
Biological sample resources BioSample; SAMN03151953
Encyclopedic resources Wikidata; Q54990987
Gene expression databases GEO; GSM136237
Polymorphism and mutation databases Cosmic; 846277
Cosmic; 1302357
Cosmic; 2037968
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28