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Cellosaurus MOLT-15 (CVCL_8150)

[Text version]
Cell line name MOLT-15
Synonyms Molt-15; MOLT 15; BCH-5
Accession CVCL_8150
Resource Identification Initiative To cite this cell line use: MOLT-15 (RRID:CVCL_8150)
Comments Problematic cell line: Contaminated. Shown to be a CTV-1 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388). Originally thought to originate from a 33 year old male patient suffering from acute myeloid leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00147.
Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Gly477Ser (c.1429G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Gly831Glu (c.2492G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6524; LCK; Simple; p.Ala353Val (c.1058C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6524; LCK; Simple; p.Pro447Leu (c.1340C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6524; LCK; Simple; p.Ala500Thr (c.1498G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7765; NF1; Simple; p.Gly1532Arg (c.4594G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Ser2523Ter (c.7568C>A); Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; 8804; PDGFRB; Simple; p.Met772Ile (c.2316G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9967; RET; Simple; p.Cys656Phe (c.1967G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Arg75Met (c.224G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Lys175Met (c.524A>T); Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1150 (CTV-1)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2784121; DOI=10.1002/hon.2900070203
Drexler H.G., Minowada J.
Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.
Hematol. Oncol. 7:115-125(1989)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8150
Biological sample resources BioSample; SAMN03151632
Encyclopedic resources Wikidata; Q54906346
Polymorphism and mutation databases Cosmic; 913415
Cosmic; 1524806
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26