ID   FL-218
AC   CVCL_8094
SY   FL218
DR   BTO; BTO_0002519
DR   cancercelllines; CVCL_8094
DR   IARC_TP53; 6002
DR   Wikidata; Q54834954
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2180570;
RX   PubMed=8847894;
RX   PubMed=8878455;
RX   PubMed=12967475;
RX   PubMed=14990977;
RX   PubMed=15028022;
CC   Population: Japanese.
CC   Doubling time: 26.7 hours (PubMed=8847894).
CC   Sequence variation: Gene fusion; HGNC; HGNC:990; BCL2 + HGNC; HGNC:5477; IGH; Name(s)=IGH-BCL2 (PubMed=12967475).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=8878455).
CC   Omics: Transcriptome analysis by microarray.
CC   Misspelling: AKA96-6; IARC_TP53=6002; Note=Not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C3209; Follicular lymphoma
DI   ORDO; Orphanet_545; Follicular lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   73Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 20
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=2180570;
RA   Amakawa R., Fukuhara S., Ohno H., Tanabe S., Horii M., Matsuyama F.,
RA   Kato I., Kakita T., Nagauchi O.;
RT   "Amplified and rearranged bcl-2 gene in two lymphoma cell lines, FL-218
RT   and FL-318, carrying a 14;18 translocation.";
RL   Cancer Res. 50:2423-2428(1990).
//
RX   PubMed=8847894;
RA   Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K.,
RA   Nakamura H., Amakawa R., Ohno H.;
RT   "Sensitivity to dexamethasone and absence of bcl-2 protein in
RT   Burkitt's lymphoma cell line (Black93) derived from a patient with
RT   acute tumor lysis syndrome: comparative study with other BL and non-BL
RT   lines.";
RL   Leukemia 10:1592-1603(1996).
//
RX   PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x; PMCID=PMC5921203;
RA   Akasaka T., Muramatsu M., Kadowaki N., Ohno H., Ishizaki K.,
RA   Yamabe H., Fukuhara S., Okuma M.;
RT   "p53 mutation in B-cell lymphoid neoplasms with reference to oncogene
RT   rearrangements associated with chromosomal translocations.";
RL   Jpn. J. Cancer Res. 87:930-937(1996).
//
RX   PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x; PMCID=PMC11160262;
RA   Maesako Y., Uchiyama T., Ohno H.;
RT   "Comparison of gene expression profiles of lymphoma cell lines from
RT   transformed follicular lymphoma, Burkitt's lymphoma and de novo
RT   diffuse large B-cell lymphoma.";
RL   Cancer Sci. 94:774-781(2003).
//
RX   PubMed=14990977; DOI=10.1038/sj.leu.2403323;
RA   Hardianti M.S., Tatsumi E., Syampurnawati M., Furuta K., Saigo K.,
RA   Nakamachi Y., Kumagai S., Ohno H., Tanabe S., Uchida M., Yasuda N.;
RT   "Activation-induced cytidine deaminase expression in follicular
RT   lymphoma: association between AID expression and ongoing mutation in
RT   FL.";
RL   Leukemia 18:826-831(2004).
//
RX   PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x;
RA   Kamimura K., Hojo H., Abe M.;
RT   "Characterization of expression of protein kinase C isozymes in human
RT   B-cell lymphoma: relationship between its expression and prognosis.";
RL   Pathol. Int. 54:224-230(2004).
//