ID   TF-1 D2
AC   CVCL_8059
SY   D2
DR   cancercelllines; CVCL_8059
DR   Wikidata; Q54817182
RX   PubMed=9038380;
CC   Population: Japanese.
CC   Characteristics: Growth factor independent clone of TF-1.
CC   Sequence variation: Gene fusion; HGNC; HGNC:15868; ABHD12 + HGNC; HGNC:1537; CBFA2T3; Name(s)=CBFA2T3-ABHD12 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Pro (c.182A>C); ClinVar=VCV000280409; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Thrfs*94 (c.752delT); ClinVar=VCV001759367; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C7152; Erythroleukemia
DI   ORDO; Orphanet_318; Acute erythroid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0559 ! TF-1
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 20
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RX   PubMed=9038380; DOI=10.1038/sj.onc.1200884;
RA   Chao J.-R., Chen C.-S., Wang T.-F., Tseng L.-H., Tsai J.-J.,
RA   Kuo M.-L., Yen J.J.-Y., Yang Yen H.-F.;
RT   "Characterization of factor-independent variants derived from TF-1
RT   hematopoietic progenitor cells: the role of the Raf/MAP kinase pathway
RT   in the anti-apoptotic effect of GM-CSF.";
RL   Oncogene 14:721-728(1997).
//