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Cellosaurus TTC-642 (CVCL_8006)

[Text version]
Cell line name TTC-642
Synonyms TTC642
Accession CVCL_8006
Resource Identification Initiative To cite this cell line use: TTC-642 (RRID:CVCL_8006)
Comments Problematic cell line: Possibly misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (STR profile).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Triche T.J.; Children's Hospital of Los Angeles; Los Angeles; USA.
Karyotypic information: 45,XX,-22 (PubMed=9559292).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Derived from site: Metastatic; Neck; UBERON=UBERON_0000974.
Sequence variations
Disease Extrarenal rhabdoid tumor (NCIt: C6586)
Rhabdoid tumor (ORDO: Orphanet_69077)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 5M
Category Cancer cell line
STR profile Source(s): DepMap

Penta D12,13
Penta E9,17

Run an STR similarity search on this cell line

PubMed=9559292; DOI=10.1097/00019606-199712000-00004
Suzuki A., Ohta S., Shimada M.
Gene expression of malignant rhabdoid tumor cell lines by reverse transcriptase-polymerase chain reaction.
Diagn. Mol. Pathol. 6:326-332(1997)

PubMed=9920784; DOI=10.1006/bbrc.1998.9968
Mori T., Fukuda Y., Kuroda H., Matsumura T., Ota S., Sugimoto T., Nakamura Y., Inazawa J.
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Biochem. Biophys. Res. Commun. 254:594-600(1999)

PubMed=10602515; DOI=10.1038/sj.onc.1203168
DeCristofaro M.F., Betz B.L., Wang W.-D., Weissman B.E.
Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors.
Oncogene 18:7559-7565(1999)

PubMed=11921280; DOI=10.1002/gcc.10052
Uno K., Takita J., Yokomori K., Tanaka Y., Ohta S., Shimada H., Gilles F.H., Sugita K., Abe S., Sako M., Hashizume K., Hayashi Y.
Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.
Genes Chromosomes Cancer 34:33-41(2002)

PubMed=12210830; DOI=10.1002/jnr.10330
Yoshida S., Narita T., Taga T., Ohta S., Takeuchi Y.
Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.
J. Neurosci. Res. 69:642-652(2002)

PubMed=24418192; DOI=10.1111/cas.12352
Takita J., Chen Y.-Y., Kato M., Ohki K., Sato Y., Ohta S., Sugita K., Nishimura R., Hoshino N., Seki M., Sanada M., Oka A., Hayashi Y., Ogawa S.
Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays.
Cancer Sci. 105:258-264(2014)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line databases/resources cancercelllines; CVCL_8006
Cell_Model_Passport; SIDM01456
DepMap; ACH-001212
Biological sample resources BioSample; SAMN10989628
Encyclopedic resources Wikidata; Q54973252
Gene expression databases GEO; GSM3145741
Polymorphism and mutation databases Cosmic; 801774
Cosmic; 802053
Cosmic; 2144785
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21