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Cellosaurus 253J-BV (CVCL_7937)

[Text version]
Cell line name 253J-BV
Synonyms 253JB-V; 253J B-V; 253JBV; 253J-Bladder-V
Accession CVCL_7937
Resource Identification Initiative To cite this cell line use: 253J-BV (RRID:CVCL_7937)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Characteristics: Metastatic phenotype. Obtained after 5 serial passages of the parent cell line in the bladder of nude mice.
Doubling time: 49 +- 5 hours (PubMed=7658585).
Microsatellite instability: Stable (MSS) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Retroperitoneal lymph node; UBERON=UBERON_0035371.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,03:01
HLA-BB*08:01,51:01
HLA-CC*07:06,12:03
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7935 (253J)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): KCLB

Markers:
AmelogeninX
CSF1PO10,12
D3S135815
D5S81810,12
D7S8209
D13S3179
FGA23,24
TH016,9.3
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=7658585; DOI=10.1016/S0022-5347(01)66923-4
Dinney C.P.N., Fishbeck R., Singh R.K., Eve B., Pathak S., Brown N., Xie B., Fan D., Bucana C.D., Fidler I.J., Killion J.J.
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice.
J. Urol. 154:1532-1538(1995)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) KCLB; 80002
Cell line databases/resources cancercelllines; CVCL_7937
Cell_Model_Passport; SIDM01624
DepMap; ACH-000026
Anatomy/cell type resources BTO; BTO:0004894
Biological sample resources BioSample; SAMN10987963
Chemistry resources PharmacoDB; 253JBV_15_2019
Encyclopedic resources Wikidata; Q54583655
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM136239
Polymorphism and mutation databases Cosmic; 846282
Cosmic; 1082645
Cosmic; 1938695
IARC_TP53; 30015
LiGeA; CCLE_144
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23