ID   21PT
AC   CVCL_7934
SY   21 PT
DR   Cell_Model_Passport; SIDM01900
DR   GEO; GSM1172849
DR   GEO; GSM1172937
DR   GEO; GSM3145618
DR   GEO; GSM3145689
DR   IARC_TP53; 3288
DR   LINCS_HMS; 51109
DR   PharmacoDB; 21PT_11_2019
DR   Wikidata; Q54583263
RX   DOI=10.1007/978-1-4612-0411-4_18;
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   PubMed=1977518;
RX   PubMed=7923592;
RX   PubMed=8482634;
RX   PubMed=20458274;
RX   PubMed=24176112;
RX   PubMed=25960936;
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
CC   Part of: JWGray breast cancer cell line panel.
CC   Characteristics: 21PT is non-tumorigenic whereas 21NT and 21MT-1/21-MT-2 cause tumors in the nude mice system.
CC   Doubling time: 35.5 +- 1.1 hours (Note=In alpha H&E medium), 42.3 +- 4.7 hours (Note=In D medium) (PubMed=8482634); 35.70 hours (JWGray panel).
CC   HLA typing: A*31:01,26:01; B*35:02,38:01; C*04:01,12:03; DRB1*04:03,04:03 (PubMed=25960936).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser33Phefs*9 (c.96_97insT); Zygosity=Unspecified (PubMed=7923592).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7931 ! 21MT-1
OI   CVCL_7932 ! 21MT-2
OI   CVCL_7933 ! 21NT
OI   CVCL_IP81 ! H16F1
OI   CVCL_IP82 ! H16N-2
OI   CVCL_IP83 ! H16N-3
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 25
//
RX   PubMed=7923592; DOI=10.1093/carcin/15.9.1969;
RA   Liu, Xiao-Long
RA   Band, Hamid
RA   Gao, Qing-Shen
RA   Wazer, David E.
RA   Chu, Qiu-Ming
RA   Band, Vimla
RT   "Tumor cell-specific loss of p53 protein in a unique in vitro model of
RT   human breast tumor progression.";
RL   Carcinogenesis 15:1969-1973(1994).
//
RX   PubMed=1977518;
RA   Band, Vimla
RA   Zajchowski, Deborah
RA   Swisshelm, Karen Lynn
RA   Trask, Douglas K.
RA   Kulesa, Victoria
RA   Cohen, Craig
RA   Connolly, James Leo
RA   Sager, Ruth
RT   "Tumor progression in four mammary epithelial cell lines derived from
RT   the same patient.";
RL   Cancer Res. 50:7351-7357(1990).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary J.
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=20458274; DOI=10.1038/labinvest.2010.97;
RA   Souter, Lesley H.
RA   Andrews, Joseph D.
RA   Zhang, Gui-Hua
RA   Cook, Amy C.
RA   Postenka, Carl O.
RA   Al-Katib, Waleed
RA   Leong, Hon S.
RA   Rodenhiser, David I.
RA   Chambers, Ann F.
RA   Tuck, Alan B.
RT   "Human 21T breast epithelial cell lines mimic breast cancer
RT   progression in vivo and in vitro and show stage-specific gene
RT   expression patterns.";
RL   Lab. Invest. 90:1247-1258(2010).
//
RX   PubMed=8482634; DOI=10.1016/0360-3016(93)90176-V;
RA   Wazer, David E.
RA   Joyce, Melita
RA   Jung, Ladonna
RA   Band, Vimla
RT   "Alterations in growth phenotype and radiosensitivity after
RT   fractionated irradiation of breast carcinoma cells from a single
RT   patient.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 26:81-88(1993).
//
RX   DOI=10.1007/978-1-4612-0411-4_18;
RA   Band, Vimla
RA   Sager, Ruth
RT   "Tumor progression in breast cancer.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.169-178; Humana Press; New York; USA (1990).
//
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz, Albert
RT   "Cell lines from human breast.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//