ID   21NT
AC   CVCL_7933
SY   21 NT
DR   cancercelllines; CVCL_7933
DR   Cell_Model_Passport; SIDM01912
DR   DepMap; ACH-002399
DR   GEO; GSM1172936
DR   GEO; GSM1172848
DR   GEO; GSM1664566
DR   GEO; GSM3145688
DR   IARC_TP53; 21719
DR   LINCS_HMS; 51108
DR   PharmacoDB; 21NT_10_2019
DR   Progenetix; CVCL_7933
DR   Wikidata; Q54583260
RX   DOI=10.1007/978-1-4612-0411-4_18;
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   PubMed=1977518;
RX   PubMed=7923592;
RX   PubMed=8482634;
RX   PubMed=20458274;
RX   PubMed=24176112;
RX   PubMed=25960936;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Characteristics: 21PT is non-tumorigenic whereas 21NT and 21MT-1/21-MT-2 cause tumors in the nude mice system.
CC   Doubling time: 31.4 +- 2.6 hours (Note=In alpha H&E medium), 38.6 +- 2.9 hours (Note=In D medium) (PubMed=8482634); 46.38 hours (JWGray panel).
CC   HLA typing: A*26:01,31:01; B*35:02,38:01; C*04:01,12:03; DRB1*04:03,04:03 (PubMed=25960936).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser33Phefs*9 (c.96_97insT); Zygosity=Unspecified (PubMed=7923592).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7931 ! 21MT-1
OI   CVCL_7932 ! 21MT-2
OI   CVCL_7934 ! 21PT
OI   CVCL_IP81 ! H16F1
OI   CVCL_IP82 ! H16N-2
OI   CVCL_IP83 ! H16N-3
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
RX   DOI=10.1007/978-1-4612-0411-4_18;
RA   Band V., Sager R.;
RT   "Tumor progression in breast cancer.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.169-178; Humana Press; New York (1990).
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz A.;
RT   "Cell lines from human breast.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994).
RX   PubMed=1977518;
RA   Band V., Zajchowski D., Swisshelm K.L., Trask D.K., Kulesa V., Cohen C.,
RA   Connolly J.L., Sager R.;
RT   "Tumor progression in four mammary epithelial cell lines derived from
RT   the same patient.";
RL   Cancer Res. 50:7351-7357(1990).
RX   PubMed=7923592; DOI=10.1093/carcin/15.9.1969;
RA   Liu X.-L., Band H., Gao Q.-S., Wazer D.E., Chu Q.-M., Band V.;
RT   "Tumor cell-specific loss of p53 protein in a unique in vitro model of
RT   human breast tumor progression.";
RL   Carcinogenesis 15:1969-1973(1994).
RX   PubMed=8482634; DOI=10.1016/0360-3016(93)90176-V;
RA   Wazer D.E., Joyce M., Jung L., Band V.;
RT   "Alterations in growth phenotype and radiosensitivity after
RT   fractionated irradiation of breast carcinoma cells from a single
RT   patient.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 26:81-88(1993).
RX   PubMed=20458274; DOI=10.1038/labinvest.2010.97;
RA   Souter L.H., Andrews J.D., Zhang G.-H., Cook A.C., Postenka C.O.,
RA   Al-Katib W., Leong H.S., Rodenhiser D.I., Chambers A.F., Tuck A.B.;
RT   "Human 21T breast epithelial cell lines mimic breast cancer
RT   progression in vivo and in vitro and show stage-specific gene
RT   expression patterns.";
RL   Lab. Invest. 90:1247-1258(2010).
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110;
RA   Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M.,
RA   Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S.,
RA   Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S.,
RA   Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J.,
RA   Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.;
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).