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Cellosaurus MOLM-14 (CVCL_7916)

[Text version]
Cell line name MOLM-14
Synonyms Molm-14; Molm 14; Molm14; MOLM14
Accession CVCL_7916
Resource Identification Initiative To cite this cell line use: MOLM-14 (RRID:CVCL_7916)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 3-4 days (PubMed=9305600); ~50 hours (DSMZ=ACC-777).
Omics: Deep quantitative phosphoproteome analysis.
Omics: H3K79me1 ChIP-seq epigenome analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (PubMed=9305600).
  • Mutation; HGNC; 3765; FLT3; Unexplicit; Internal tandem duplication (FLT3-ITD); ClinVar=VCV000016270; Zygosity=Unspecified (PubMed=12529668).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2119 ! MOLM-13
Sex of cell Male
Age at sampling 20Y
Category Cancer cell line
STR profile Source(s): COG; DepMap=ACH-001574; DSMZ=ACC-777; JCRB=JCRB1812

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133823,25
D3S135815
D5S81810,11
D7S82010,12
D8S117913,14
D13S31710,11
D16S53910,11
D18S5113,15
D19S43312,14
D21S1130,31
FGA21,23
Penta D9,12
Penta E18,19
TH017
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=9305600; DOI=10.1038/sj.leu.2400768
Matsuo Y., MacLeod R.A.F., Uphoff C.C., Drexler H.G., Nishizaki C., Katayama Y., Kimura G., Fujii N., Omoto E., Harada M., Orita K.
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).
Leukemia 11:1469-1477(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12529668; DOI=10.1038/sj.leu.2402740
Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.
FLT3 mutations in acute myeloid leukemia cell lines.
Leukemia 17:120-124(2003)

PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268
Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A., Tucker M., Kornhauser J.M., Ren J.-M., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:E19169-E19169(2011)

Cross-references
Cell line collections (Providers) DSMZ; ACC-777
JCRB; JCRB1812
Cell line databases/resources Cell_Model_Passport; SIDM00436
DepMap; ACH-001574
DSMZCellDive; ACC-777
Lonza; 978
Anatomy/cell type resources BTO; BTO:0005720
Chemistry resources ChEMBL-Cells; CHEMBL3706571
ChEMBL-Targets; CHEMBL3706570
PubChem_Cell_line; CVCL_7916
Encyclopedic resources Wikidata; Q54906323
Experimental variables resources EFO; EFO_0022446
Gene expression databases GEO; GSM2037134
GEO; GSM2037135
GEO; GSM3145724
Polymorphism and mutation databases Cosmic; 787418
Cosmic; 1150898
Cosmic; 1281333
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number26