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Cellosaurus GM00847 (CVCL_7908)

[Text version]
Cell line name GM00847
Synonyms LN-SV; LNSV; GM-847; GM 847; GM847
Accession CVCL_7908
Resource Identification Initiative To cite this cell line use: GM00847 (RRID:CVCL_7908)
Comments Population: African American.
Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Lesch-Nyhan syndrome (NCIt: C61255)
Lesch-Nyhan syndrome (ORDO: Orphanet_510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F127 (GM02063)
Children:
CVCL_7252 (CL 21)CVCL_D343 (GM15836)CVCL_7947 (GM847/ATRkd)
CVCL_C1HE (GM847/hTERT-3)CVCL_C1HF (GM847/hTERT-6)
Sex of cell Male
Age at sampling 5Y6M
Category Transformed cell line
Publications

PubMed=174085; DOI=10.1073/pnas.72.12.4971; PMCID=PMC388856
Stiles C.D., Desmond W. Jr., Sato G.H., Saier M.H. Jr.
Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice.
Proc. Natl. Acad. Sci. U.S.A. 72:4971-4975(1975)

PubMed=1260760
Stiles C.D., Desmond W. Jr., Chuman L.M., Sato G.H., Saier M.H. Jr.
Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse.
Cancer Res. 36:1353-1360(1976)

DOI=10.5962/bhl.title.4090
Coriell L.L., Greene A.E.
The human genetic mutant cell repository: list of genetic variants, chromosomal aberrations and normal cell cultures submitted to the repository. 4th edition. October 1977.
(In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda; USA (1977)

PubMed=191830; DOI=10.1073/pnas.74.3.1142; PMCID=PMC430625
Koprowski H., Croce C.M.
Tumorigenicity of simian virus 40-transformed human cells and mouse-human hybrids in nude mice.
Proc. Natl. Acad. Sci. U.S.A. 74:1142-1146(1977)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042; PMCID=PMC281901
Pereira-Smith O.M., Smith J.R.
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

CLPUB00447
Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

PubMed=11359895; DOI=10.1128/mcb.21.12.3862-3875.2001; PMCID=PMC87050
Perrem K., Colgin L.M., Neumann A.A., Yeager T.R., Reddel R.R.
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells.
Mol. Cell. Biol. 21:3862-3875(2001)

PubMed=12361951; DOI=10.1074/jbc.M207937200
Donahue S.L., Campbell C.
A DNA double strand break repair defect in Fanconi anemia fibroblasts.
J. Biol. Chem. 277:46243-46247(2002)

CLPUB00712
Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=26001292; DOI=10.18632/oncotarget.3846; PMCID=PMC4599288
Napier C.E., Huschtscha L.I., Harvey A., Bower K., Noble J.R., Hendrickson E.A., Reddel R.R.
ATRX represses alternative lengthening of telomeres.
Oncotarget 6:16543-16558(2015)

Cross-references
Cell line collections (Providers) Coriell; GM00847
Cell line databases/resources CLO; CLO_0029655
Encyclopedic resources Wikidata; Q54836472
Experimental variables resources EFO; EFO_0022519
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number24