ID   UT-SCC-8
AC   CVCL_7869
SY   UTSCC8; University of Turku-Squamous Cell Carcinoma-8
DR   cancercelllines; CVCL_7869
DR   GEO; GSM2883356
DR   GEO; GSM2888819
DR   IARC_TP53; 11065
DR   Wikidata; Q54992191
RX   PubMed=8782485;
RX   PubMed=16715129;
RX   PubMed=17312569;
RX   PubMed=29970484;
RX   PubMed=33802339;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile255Phe (c.763A>T); ClinVar=VCV000376621; Zygosity=Unspecified (PubMed=8782485; PubMed=33802339).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
ST   Source(s): PubMed=33802339
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8,14
ST   D16S539: 12
ST   D18S51: 13
ST   D19S433: 13
ST   D21S11: 30,31.2
ST   D2S1338: 19,25
ST   D3S1358: 15
ST   D5S818: 10,11
ST   D7S820: 10
ST   D8S1179: 13,14
ST   FGA: 21
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 14,16
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 16
//
RX   PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x;
RA   Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O.,
RA   Rytomaa T.;
RT   "p53 mutations associated with increased sensitivity to ionizing
RT   radiation in human head and neck cancer cell lines.";
RL   Cell Prolif. 29:219-230(1996).
//
RX   PubMed=16715129; DOI=10.1038/sj.onc.1209690;
RA   Jarvinen A.-K., Autio R., Haapa-Paananen S., Wolf M., Saarela M.,
RA   Grenman R., Leivo I., Kallioniemi O.-P., Makitie A.A., Monni O.;
RT   "Identification of target genes in laryngeal squamous cell carcinoma
RT   by high-resolution copy number and gene expression microarray
RT   analyses.";
RL   Oncogene 25:6997-7008(2006).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=29970484; DOI=10.1158/1535-7163.MCT-17-0733;
RA   Lepikhova T., Karhemo P.-R., Louhimo R., Yadav B., Murumagi A.,
RA   Kulesskiy E., Kivento M., Sihto H., Grenman R., Syrjanen S.M.,
RA   Kallioniemi O.-P., Aittokallio T., Wennerberg K., Joensuu H., Monni O.;
RT   "Drug-sensitivity screening and genomic characterization of 45
RT   HPV-negative head and neck carcinoma cell lines for novel biomarkers
RT   of drug efficacy.";
RL   Mol. Cancer Ther. 17:2060-2071(2018).
//
RX   PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143;
RA   Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.;
RT   "Genotyping and characterization of HPV status, hypoxia, and
RT   radiosensitivity in 22 head and neck cancer cell lines.";
RL   Cancers (Basel) 13:1069.1-1069.12(2021).
//