ID   UT-SCC-7
AC   CVCL_7868
SY   UT-SCC7; University of Turku-Squamous Cell Carcinoma-7
DR   cancercelllines; CVCL_7868
DR   IARC_TP53; 11067
DR   Wikidata; Q54992189
RX   PubMed=8782485;
RX   PubMed=9187133;
RX   PubMed=17312569;
RX   PubMed=22427941;
RX   PubMed=27305645;
RX   PubMed=28322200;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Unspecified (PubMed=8782485).
CC   Derived from site: Metastatic; Temple, skin; UBERON=UBERON_8480028.
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 13
//
RX   PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x;
RA   Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O.,
RA   Rytomaa T.;
RT   "p53 mutations associated with increased sensitivity to ionizing
RT   radiation in human head and neck cancer cell lines.";
RL   Cell Prolif. 29:219-230(1996).
//
RX   PubMed=9187133;
RA   Soukka T., Salmi M., Joensuu H., Hakkinen L., Sointu P., Koulu L.,
RA   Kalimo K., Klemi P., Grenman R., Jalkanen S.T.;
RT   "Regulation of CD44v6-containing isoforms during proliferation of
RT   normal and malignant epithelial cells.";
RL   Cancer Res. 57:2281-2289(1997).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=22427941; DOI=10.1371/journal.pone.0033041; PMCID=PMC3299721;
RA   Toriseva M., Ala-aho R., Peltonen S., Peltonen J., Grenman R.,
RA   Kahari V.-M.;
RT   "Keratinocyte growth factor induces gene expression signature
RT   associated with suppression of malignant phenotype of cutaneous
RT   squamous carcinoma cells.";
RL   PLoS ONE 7:E33041-E33041(2012).
//
RX   PubMed=27305645; DOI=10.1111/exd.13109;
RA   Farshchian M., Nissinen L., Grenman R., Kahari V.-M.;
RT   "Dasatinib promotes apoptosis of cutaneous squamous carcinoma cells by
RT   regulating activation of ERK1/2.";
RL   Exp. Dermatol. 26:89-92(2017).
//
RX   PubMed=28322200; DOI=10.1016/j.ajpath.2017.01.006;
RA   Riihila P., Nissinen L., Farshchian M., Kallajoki M., Kivisaari A.,
RA   Meri S., Grenman R., Peltonen S., Peltonen J., Pihlajaniemi T.,
RA   Heljasvaara R., Kahari V.-M.;
RT   "Complement component C3 and complement factor B promote growth of
RT   cutaneous squamous cell carcinoma.";
RL   Am. J. Pathol. 187:1186-1197(2017).
//