ID   UT-SCC-54B
AC   CVCL_7864
SY   University of Turku-Squamous Cell Carcinoma-54B
DR   cancercelllines; CVCL_7864
DR   Wikidata; Q54992154
RX   DOI=10.1158/1538-7445.AM2020-507;
RX   PubMed=15287027;
RX   PubMed=17312569;
RX   PubMed=30135316;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Unspecified (PubMed=15287027).
CC   Omics: Deep exome analysis.
CC   Caution: UT-SCC-54A, UT-SCC-54B and UT-SCC-54C are supposed to originate from the same patient but the STR profile of UT-SCC-54C is totally different from that of the two other cell lines.
CC   Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
ST   Source(s): PubMed=30135316
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 11,12
ST   D18S51: 16
ST   D19S433: 14
ST   D21S11: 31,32.2
ST   D2S1338: 20,24
ST   D3S1358: 17
ST   D5S818: 11
ST   D7S820: 12
ST   D8S1179: 10,14
ST   FGA: 21,26
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 14,18
DI   NCIt; C4040; Buccal mucosa squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7863 ! UT-SCC-54A
OI   CVCL_A7DW ! UT-SCC-54C
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 14
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RX   DOI=10.1158/1538-7445.AM2020-507;
RA   Kondratyev M.K., Pesic A., Dvorkin-Sheva A., Ketela T., Moffat J.,
RA   Koritzinsky M., Wouters B.G.;
RT   "Repurposing of FDA approved drugs for treatment of metastatic HNSCC.";
RL   Cancer Res. 80 Suppl. 16:507-507(2020).
//
RX   PubMed=15287027; DOI=10.1002/gcc.20066;
RA   Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y.,
RA   Grenman R., Fisher S.G., Carey T.E.;
RT   "Loss of chromosome arm 18q with tumor progression in head and neck
RT   squamous cancer.";
RL   Genes Chromosomes Cancer 41:145-154(2004).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=30135316; DOI=10.1172/jci.insight.122204; PMCID=PMC6141174;
RA   Jamieson S.M.F., Tsai P., Kondratyev M.K., Budhani P., Liu A.,
RA   Senzer N.N., Chiorean E.G., Jalal S.I., Nemunaitis J.J., Kee D.,
RA   Shome A., Wong W.W., Li D., Poonawala-Lohani N., Kakadia P.M.,
RA   Knowlton N.S., Lynch C.R.H., Hong C.R., Lee T.W., Grenman R.,
RA   Caporiccio L., McKee T.D., Zaidi M., Butt S., Macann A.M.J.,
RA   McIvor N.P., Chaplin J.M., Hicks K.O., Bohlander S.K., Wouters B.G.,
RA   Hart C.P., Print C.G., Wilson W.R., Curran M.A., Hunter F.W.;
RT   "Evofosfamide for the treatment of human papillomavirus-negative head
RT   and neck squamous cell carcinoma.";
RL   JCI Insight 3:e122204.1-e122204.19(2018).
//