ID   UT-SCC-42A
AC   CVCL_7847
SY   UTSCC42A; University of Turku-Squamous Cell Carcinoma-42A
DR   cancercelllines; CVCL_7847
DR   GEO; GSM2883372
DR   GEO; GSM2888835
DR   Wikidata; Q54992130
RX   DOI=10.1158/1538-7445.AM2020-507;
RX   PubMed=15287027;
RX   PubMed=16715129;
RX   PubMed=17312569;
RX   PubMed=29970484;
RX   PubMed=30135316;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Homozygous (PubMed=15287027; PubMed=29970484).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
ST   Source(s): PubMed=30135316
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 8,11
ST   D16S539: 11,13
ST   D18S51: 15
ST   D19S433: 14,15.2
ST   D21S11: 28,30
ST   D2S1338: 17,26
ST   D3S1358: 14
ST   D5S818: 11
ST   D7S820: 7,10
ST   D8S1179: 11,13
ST   FGA: 23
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7848 ! UT-SCC-42B
SX   Male
AG   43Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 15
//
RX   DOI=10.1158/1538-7445.AM2020-507;
RA   Kondratyev M.K., Pesic A., Dvorkin-Sheva A., Ketela T., Moffat J.,
RA   Koritzinsky M., Wouters B.G.;
RT   "Repurposing of FDA approved drugs for treatment of metastatic HNSCC.";
RL   Cancer Res. 80 Suppl. 16:507-507(2020).
//
RX   PubMed=15287027; DOI=10.1002/gcc.20066;
RA   Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y.,
RA   Grenman R., Fisher S.G., Carey T.E.;
RT   "Loss of chromosome arm 18q with tumor progression in head and neck
RT   squamous cancer.";
RL   Genes Chromosomes Cancer 41:145-154(2004).
//
RX   PubMed=16715129; DOI=10.1038/sj.onc.1209690;
RA   Jarvinen A.-K., Autio R., Haapa-Paananen S., Wolf M., Saarela M.,
RA   Grenman R., Leivo I., Kallioniemi O.-P., Makitie A.A., Monni O.;
RT   "Identification of target genes in laryngeal squamous cell carcinoma
RT   by high-resolution copy number and gene expression microarray
RT   analyses.";
RL   Oncogene 25:6997-7008(2006).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=29970484; DOI=10.1158/1535-7163.MCT-17-0733;
RA   Lepikhova T., Karhemo P.-R., Louhimo R., Yadav B., Murumagi A.,
RA   Kulesskiy E., Kivento M., Sihto H., Grenman R., Syrjanen S.M.,
RA   Kallioniemi O.-P., Aittokallio T., Wennerberg K., Joensuu H., Monni O.;
RT   "Drug-sensitivity screening and genomic characterization of 45
RT   HPV-negative head and neck carcinoma cell lines for novel biomarkers
RT   of drug efficacy.";
RL   Mol. Cancer Ther. 17:2060-2071(2018).
//
RX   PubMed=30135316; DOI=10.1172/jci.insight.122204; PMCID=PMC6141174;
RA   Jamieson S.M.F., Tsai P., Kondratyev M.K., Budhani P., Liu A.,
RA   Senzer N.N., Chiorean E.G., Jalal S.I., Nemunaitis J.J., Kee D.,
RA   Shome A., Wong W.W., Li D., Poonawala-Lohani N., Kakadia P.M.,
RA   Knowlton N.S., Lynch C.R.H., Hong C.R., Lee T.W., Grenman R.,
RA   Caporiccio L., McKee T.D., Zaidi M., Butt S., Macann A.M.J.,
RA   McIvor N.P., Chaplin J.M., Hicks K.O., Bohlander S.K., Wouters B.G.,
RA   Hart C.P., Print C.G., Wilson W.R., Curran M.A., Hunter F.W.;
RT   "Evofosfamide for the treatment of human papillomavirus-negative head
RT   and neck squamous cell carcinoma.";
RL   JCI Insight 3:e122204.1-e122204.19(2018).
//