ID   UM-SCC-4
AC   CVCL_7751
SY   UMSCC-4; UMSCC4; SCC4; University of Michigan-Squamous Cell Carcinoma-4
DR   cancercelllines; CVCL_7751
DR   Cosmic; 1130351
DR   Cosmic; 1483457
DR   Cosmic; 2131864
DR   Cosmic; 2296305
DR   IARC_TP53; 23608
DR   Wikidata; Q54990861
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1851275;
RX   PubMed=3855324;
RX   PubMed=16203773;
RX   PubMed=17312569;
RX   PubMed=19760794;
RX   PubMed=21868764;
RX   PubMed=25275298;
RX   PubMed=28196595;
RX   PubMed=29156801;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Unspecified (PubMed=25275298).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (PubMed=16203773).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
ST   Source(s): PubMed=19760794; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 16
ST   D21S11: 28
ST   D3S1358: 17
ST   D5S818: 11
ST   D7S820: 9,10
ST   D8S1179: 13,15
ST   FGA: 26
ST   TH01: 7
ST   TPOX: 9,10
ST   vWA: 17,18
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1851275; DOI=10.1177/019459989110400304;
RA   Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D.,
RA   Carey T.E.;
RT   "Human papillomavirus DNA sequences in cell lines derived from head
RT   and neck squamous cell carcinomas.";
RL   Otolaryngol. Head Neck Surg. 104:303-310(1991).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378;
RA   Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L.,
RA   Carey T.E., Grenman R., Dunne A.A., Werner J.A.;
RT   "Reduced cisplatin sensitivity of head and neck squamous cell
RT   carcinoma cell lines correlates with mutations affecting the
RT   COOH-terminal nuclear localization signal of p53.";
RL   Clin. Cancer Res. 11:6845-6852(2005).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417;
RA   Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y.,
RA   Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.;
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//