ID   UM-SCC-38
AC   CVCL_7749
SY   UMSCC-38; UMSCC38; University of Michigan-Squamous Cell Carcinoma-38
DR   BTO; BTO:0002715
DR   cancercelllines; CVCL_7749
DR   Cosmic; 948035
DR   Cosmic; 2513916
DR   Cosmic; 2602599
DR   IARC_TP53; 25910
DR   Wikidata; Q54990858
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1851275;
RX   PubMed=1958593;
RX   PubMed=8033114;
RX   PubMed=17312569;
RX   PubMed=18006756;
RX   PubMed=19760794;
RX   PubMed=23613873;
RX   PubMed=28196595;
RX   PubMed=31541927;
RX   PubMed=32574978;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Mutation; HGNC; 3595; FAT1; Simple; p.Met3586Thr (c.10757T>C); ClinVar=VCV000785111; Zygosity=Homozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys132Asn (c.396G>T); ClinVar=VCV000634773; Zygosity=Homozygous (PubMed=18006756; PubMed=23613873; PubMed=31541927).
CC   Omics: Genome sequenced (low read coverage).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Derived from site: In situ; Oral cavity, tonsil, tonsillar fossa; UBERON=UBERON_0035228.
ST   Source(s): PubMed=19760794
ST   Amelogenin: X,Y
ST   D13S317: 10,11
ST   D18S51: 19
ST   D21S11: 27,29
ST   D3S1358: 18
ST   D5S818: 12
ST   D7S820: 10
ST   D8S1179: 14,15
ST   FGA: 28
ST   vWA: 17,18
DI   NCIt; C8183; Tonsillar squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1851275; DOI=10.1177/019459989110400304;
RA   Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D.,
RA   Carey T.E.;
RT   "Human papillomavirus DNA sequences in cell lines derived from head
RT   and neck squamous cell carcinomas.";
RL   Otolaryngol. Head Neck Surg. 104:303-310(1991).
//
RX   PubMed=1958593; DOI=10.1002/gcc.2870030406;
RA   Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J.,
RA   Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S.,
RA   Carey T.E.;
RT   "11p deletions and breakpoints in squamous cell carcinoma: association
RT   with altered reactivity with the UM-E7 antibody.";
RL   Genes Chromosomes Cancer 3:272-282(1991).
//
RX   PubMed=8033114;
RA   Orr R.B., Kamen B.A.;
RT   "UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a
RT   mutant nonfunctional folate receptor.";
RL   Cancer Res. 54:3905-3911(1994).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591;
RA   Friedman J., Nottingham L., Duggal P., Pernas F.G., Yan B., Yang X.-P.,
RA   Chen Z., Van Waes C.;
RT   "Deficient TP53 expression, function, and cisplatin sensitivity are
RT   restored by quinacrine in head and neck cancer.";
RL   Clin. Cancer Res. 13:6568-6578(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=23613873; DOI=10.1371/journal.pone.0061555;
RA   Martens-de Kemp S.R., Dalm S.U., Wijnolts F.M.J., Brink A.,
RA   Honeywell R.J., Peters G.J., Braakhuis B.J.M., Brakenhoff R.H.;
RT   "DNA-bound platinum is the major determinant of cisplatin sensitivity
RT   in head and neck squamous carcinoma cells.";
RL   PLoS ONE 8:E61555-E61555(2013).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004;
RA   van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I.,
RA   Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.;
RT   "Characterization of a head and neck cancer-derived cell line panel
RT   confirms the distinct TP53-proficient copy number-silent subclass.";
RL   Oral Oncol. 98:53-61(2019).
//
RX   PubMed=32574978; DOI=10.1016/j.tranon.2020.100808;
RA   Nair T.S., Thomas T.B., Yang L., Kakaraparthi B.N., Morris A.C.,
RA   Clark A.M., Campredon L.P., Brouwer A.F., Eisenberg M.C., Meza R.,
RA   Carey T.E.;
RT   "Characteristics of head and neck squamous cell carcinoma cell lines
RT   reflect human tumor biology independent of primary etiologies and HPV
RT   status.";
RL   Transl. Oncol. 13:100808.1-100808.9(2020).
//