ID   UM-SCC-25
AC   CVCL_7735
SY   UMSCC-25; UMSCC25; SCC25; UMC-25; UMC25; University of Michigan-Squamous Cell Carcinoma-25
DR   cancercelllines; CVCL_7735
DR   Cosmic; 1130359
DR   Cosmic; 2131863
DR   GEO; GSM960575
DR   GEO; GSM960577
DR   GEO; GSM960579
DR   GEO; GSM960581
DR   GEO; GSM960583
DR   GEO; GSM960586
DR   GEO; GSM960588
DR   GEO; GSM3631272
DR   IARC_TP53; 21102
DR   Progenetix; CVCL_7735
DR   Wikidata; Q54990841
RX   PubMed=12884349;
RX   PubMed=17312569;
RX   PubMed=19760794;
RX   PubMed=21868764;
RX   PubMed=28196595;
RX   PubMed=29156801;
RX   PubMed=31090975;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=12884349).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): PubMed=19760794; PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 10,15
ST   D13S317: 11
ST   D16S539: 10,12
ST   D18S51: 19
ST   D21S11: 27
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 12,13
ST   D8S1179: 13,14
ST   FGA: 21
ST   TH01: 6,9
ST   TPOX: 8,9
ST   vWA: 19
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "P53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=31090975; DOI=10.1002/hed.25803;
RA   Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J.,
RA   Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E.,
RA   Brenner J.C.;
RT   "The molecular landscape of the University of Michigan laryngeal
RT   squamous cell carcinoma cell line panel.";
RL   Head Neck 41:3114-3124(2019).
//