ID   UM-SCC-17B
AC   CVCL_7725
SY   UMSCC-17B; UMSCC17B; University of Michigan-Squamous Cell Carcinoma-17B
DR   BTO; BTO:0002711
DR   cancercelllines; CVCL_7725
DR   Cosmic; 948032
DR   Cosmic; 2296307
DR   Cosmic; 2602596
DR   GEO; GSM3631269
DR   IARC_TP53; 21101
DR   Millipore; SCC075
DR   Progenetix; CVCL_7725
DR   Wikidata; Q54990828
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1851275;
RX   PubMed=1958593;
RX   PubMed=2790823;
RX   PubMed=3855324;
RX   PubMed=6417595;
RX   PubMed=12884349;
RX   PubMed=15287027;
RX   PubMed=16331601;
RX   PubMed=16785414;
RX   PubMed=17312569;
RX   PubMed=18487078;
RX   PubMed=19760794;
RX   PubMed=21868764;
RX   PubMed=25275298;
RX   PubMed=26754630;
RX   PubMed=29156801;
RX   PubMed=31090975;
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=18487078).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=12884349).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
ST   Source(s): Millipore; PubMed=19760794; PubMed=21868764; PubMed=25275298
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,13
ST   D16S539: 10,11
ST   D18S51: 22
ST   D21S11: 28
ST   D3S1358: 15,18
ST   D5S818: 11
ST   D7S820: 13
ST   D8S1179: 12,13
ST   FGA: 20,22
ST   Penta D: 10
ST   Penta E: 5,19
ST   TH01: 6,8
ST   TPOX: 10,11
ST   vWA: 14,17
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5G90 ! UM-Ly(ebv)-17
OI   CVCL_7724 ! UM-SCC-17A
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1851275; DOI=10.1177/019459989110400304;
RA   Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D.,
RA   Carey T.E.;
RT   "Human papillomavirus DNA sequences in cell lines derived from head
RT   and neck squamous cell carcinomas.";
RL   Otolaryngol. Head Neck Surg. 104:303-310(1991).
//
RX   PubMed=1958593; DOI=10.1002/gcc.2870030406;
RA   Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J.,
RA   Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S.,
RA   Carey T.E.;
RT   "11p deletions and breakpoints in squamous cell carcinoma: association
RT   with altered reactivity with the UM-E7 antibody.";
RL   Genes Chromosomes Cancer 3:272-282(1991).
//
RX   PubMed=2790823;
RA   Carey T.E., Van Dyke D.L., Worsham M.J., Bradford C.R., Babu V.R.,
RA   Schwartz D.R., Hsu S., Baker S.R.;
RT   "Characterization of human laryngeal primary and metastatic squamous
RT   cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.";
RL   Cancer Res. 49:6098-6107(1989).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=6417595; DOI=10.1177/019459988309100503;
RA   Carey T.E., Kimmel K.A., Schwartz D.R., Richter D.E., Baker S.R.,
RA   Krause C.J.;
RT   "Antibodies to human squamous cell carcinoma.";
RL   Otolaryngol. Head Neck Surg. 91:482-491(1983).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "P53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=15287027; DOI=10.1002/gcc.20066;
RA   Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y.,
RA   Grenman R., Fisher S.G., Carey T.E.;
RT   "Loss of chromosome arm 18q with tumor progression in head and neck
RT   squamous cancer.";
RL   Genes Chromosomes Cancer 41:145-154(2004).
//
RX   PubMed=16331601; DOI=10.1002/ijc.21514;
RA   Muller A., Sonkoly E., Eulert C., Gerber P.A., Kubitza R.,
RA   Schirlau K., Franken-Kunkel P., Poremba C., Snyderman C.H., Klotz L.-O.,
RA   Ruzicka T., Bier H., Zlotnik A., Whiteside T.L., Homey B.,
RA   Hoffmann T.K.;
RT   "Chemokine receptors in head and neck cancer: association with
RT   metastatic spread and regulation during chemotherapy.";
RL   Int. J. Cancer 118:2147-2157(2006).
//
RX   PubMed=16785414; DOI=10.1001/archotol.132.6.668;
RA   Worsham M.J., Chen K.M., Meduri V., Nygren A.O.H., Errami A.,
RA   Schouten J.P., Benninger M.S.;
RT   "Epigenetic events of disease progression in head and neck squamous
RT   cell carcinoma.";
RL   Arch. Otolaryngol. Head Neck Surg. 132:668-677(2006).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006;
RA   Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L.,
RA   Klussmann J.P., Hafner D., Schuler P., Friebe-Hoffmann U.,
RA   Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H.,
RA   Balz V.;
RT   "Alterations in the p53 pathway and their association with radio- and
RT   chemosensitivity in head and neck squamous cell carcinoma.";
RL   Oral Oncol. 44:1100-1109(2008).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417;
RA   Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y.,
RA   Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.;
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//
RX   PubMed=26754630; DOI=10.1186/s13046-016-0284-4;
RA   Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S.,
RA   Ito Y., Myers J.N., Oridate N.;
RT   "JunB promotes cell invasion, migration and distant metastasis of head
RT   and neck squamous cell carcinoma.";
RL   J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=31090975; DOI=10.1002/hed.25803;
RA   Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J.,
RA   Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E.,
RA   Brenner J.C.;
RT   "The molecular landscape of the University of Michigan laryngeal
RT   squamous cell carcinoma cell line panel.";
RL   Head Neck 41:3114-3124(2019).
//