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Cellosaurus UM-SCC-17A (CVCL_7724)

[Text version]
Cell line name UM-SCC-17A
Synonyms UM-SCC 17A; UMSCC-17A; UMSCC17A; UM-SCC17A; SCC17A; University of Michigan-Squamous Cell Carcinoma-17A
Accession CVCL_7724
Resource Identification Initiative To cite this cell line use: UM-SCC-17A (RRID:CVCL_7724)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9T71 (UM-SCC-17As)
Originate from same individual CVCL_5G90 ! UM-Ly(ebv)-17
CVCL_7725 ! UM-SCC-17B
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): Millipore; PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,18
D5S81811
D7S82013
D8S117912,13
D13S31711,13
D16S53910,11
D18S5117,22
D21S1128
FGA20,22
Penta D10
Penta E5,19
TH016,8
TPOX10,11
vWA14,17

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=6417595; DOI=10.1177/019459988309100503
Carey T.E., Kimmel K.A., Schwartz D.R., Richter D.E., Baker S.R., Krause C.J.
Antibodies to human squamous cell carcinoma.
Otolaryngol. Head Neck Surg. 91:482-491(1983)

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Baker S.R.
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=2790823
Carey T.E., Van Dyke D.L., Worsham M.J., Bradford C.R., Babu V.R., Schwartz D.R., Hsu S., Baker S.R.
Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.
Cancer Res. 49:6098-6107(1989)

PubMed=1851275; DOI=10.1177/019459989110400304
Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D., Carey T.E.
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J., Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S., Carey T.E.
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=8679156; DOI=10.1007/BF00178278
Koldovsky P., Haas I., Bier H., Ganzer U.
Immunohistochemical examination of 11 cell lines derived from human head and neck squamous cell carcinomas, their recurrences or metastases.
Eur. Arch. Otorhinolaryngol. 252:359-365(1995)

PubMed=15287027; DOI=10.1002/gcc.20066
Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y., Grenman R., Fisher S.G., Carey T.E.
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=15495191; DOI=10.1002/gcc.20119
Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=16331601; DOI=10.1002/ijc.21514
Muller A., Sonkoly E., Eulert C., Gerber P.A., Kubitza R., Schirlau K., Franken-Kunkel P., Poremba C., Snyderman C.H., Klotz L.-O., Ruzicka T., Bier H., Zlotnik A., Whiteside T.L., Homey B., Hoffmann T.K.
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Int. J. Cancer 118:2147-2157(2006)

PubMed=16785414; DOI=10.1001/archotol.132.6.668
Worsham M.J., Chen K.M., Meduri V., Nygren A.O.H., Errami A., Schouten J.P., Benninger M.S.
Epigenetic events of disease progression in head and neck squamous cell carcinoma.
Arch. Otolaryngol. Head Neck Surg. 132:668-677(2006)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L., Klussmann J.P., Hafner D., Schuler P., Friebe-Hoffmann U., Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H., Balz V.
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=19760794; DOI=10.1002/hed.21198
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=32574978; DOI=10.1016/j.tranon.2020.100808
Nair T.S., Thomas T.B., Yang L., Kakaraparthi B.N., Morris A.C., Clark A.M., Campredon L.P., Brouwer A.F., Eisenberg M.C., Meza R., Carey T.E.
Characteristics of head and neck squamous cell carcinoma cell lines reflect human tumor biology independent of primary etiologies and HPV status.
Transl. Oncol. 13:100808.1-100808.9(2020)

Cross-references
Cell line collections (Providers) Millipore; SCC074
Anatomy/cell type resources BTO; BTO:0004022
Encyclopedic resources Wikidata; Q54990826
Polymorphism and mutation databases Cosmic; 932290
Cosmic; 948031
Cosmic; 1130355
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number24