ID   UM-SCC-14C
AC   CVCL_7721
SY   UM-SCC 14C; UMSCC-14C; UMSCC14C; UM-SCC14C; University of Michigan-Squamous Cell Carcinoma-14C; 14C
DR   cancercelllines; CVCL_7721
DR   CLS; 300370
DR   Cosmic; 932289
DR   Wikidata; Q54990813
RX   PubMed=3335022;
RX   PubMed=8679156;
RX   PubMed=9041179;
RX   PubMed=9139877;
RX   PubMed=10956384;
RX   PubMed=15287027;
RX   PubMed=15495191;
RX   PubMed=17312569;
RX   PubMed=18487078;
RX   PubMed=19760794;
RX   PubMed=20947470;
RX   PubMed=23613873;
RX   PubMed=26122845;
RX   PubMed=31541927;
CC   Population: Caucasian.
CC   Doubling time: 27 +- 4 hours (PubMed=9139877).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=15495191; PubMed=18487078; PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 7133; KMT2D; Simple; p.Arg1324Thr (c.3971G>C); Zygosity=Heterozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys277_Glu286del (c.829_858del30); Zygosity=Heterozygous (PubMed=15287027; PubMed=18487078; PubMed=23613873; PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Ser (c.840A>T); ClinVar=VCV000988616; Zygosity=Heterozygous (PubMed=15287027; PubMed=18487078; PubMed=23613873; PubMed=31541927).
CC   Omics: Genome sequenced (low read coverage).
CC   Discontinued: CLS; 300370; true.
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
ST   Source(s): CLS=300370; PubMed=19760794
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 15
ST   D21S11: 29
ST   D3S1358: 15
ST   D5S818: 11,14
ST   D7S820: 9,10
ST   D8S1179: 8,13
ST   FGA: 20,21
ST   Penta D: 12,16
ST   Penta E: 7
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 14,18
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7719 ! UM-SCC-14A
OI   CVCL_7720 ! UM-SCC-14B
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
//
RX   PubMed=3335022;
RA   Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J.,
RA   Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.;
RT   "Feasibility of drug screening with panels of human tumor cell lines
RT   using a microculture tetrazolium assay.";
RL   Cancer Res. 48:589-601(1988).
//
RX   PubMed=8679156; DOI=10.1007/BF00178278;
RA   Koldovsky P., Haas I., Bier H., Ganzer U.;
RT   "Immunohistochemical examination of 11 cell lines derived from human
RT   head and neck squamous cell carcinomas, their recurrences or
RT   metastases.";
RL   Eur. Arch. Otorhinolaryngol. 252:359-365(1995).
//
RX   PubMed=9041179;
RA   Frank C.J., McClatchey K.D., Devaney K.O., Carey T.E.;
RT   "Evidence that loss of chromosome 18q is associated with tumor
RT   progression.";
RL   Cancer Res. 57:824-827(1997).
//
RX   PubMed=9139877; DOI=10.1002/(SICI)1097-0215(19970502)71:3<410::AID-IJC18>3.0.CO;2-J;
RA   Welters M.J.P., Fichtinger-Schepman A.M.J., Baan R.A., Hermsen M.A.J.A.,
RA   van der Vijgh W.J.F., Cloos J., Braakhuis B.J.M.;
RT   "Relationship between the parameters cellular differentiation,
RT   doubling time and platinum accumulation and cisplatin sensitivity in a
RT   panel of head and neck cancer cell lines.";
RL   Int. J. Cancer 71:410-415(1997).
//
RX   PubMed=10956384; DOI=10.1002/1097-0215(20000915)87:6<771::AID-IJC2>3.0.CO;2-V;
RA   Backus H.H.J., Pinedo H.M., Wouters D., Padron J.M., Molders N.,
RA   van der Wilt C.L., van Groeningen C.J., Jansen G., Peters G.J.;
RT   "Folate depletion increases sensitivity of solid tumor cell lines to
RT   5-fluorouracil and antifolates.";
RL   Int. J. Cancer 87:771-778(2000).
//
RX   PubMed=15287027; DOI=10.1002/gcc.20066;
RA   Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y.,
RA   Grenman R., Fisher S.G., Carey T.E.;
RT   "Loss of chromosome arm 18q with tumor progression in head and neck
RT   squamous cancer.";
RL   Genes Chromosomes Cancer 41:145-154(2004).
//
RX   PubMed=15495191; DOI=10.1002/gcc.20119;
RA   Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.;
RT   "Homozygous deletions of CDKN2A caused by alternative mechanisms in
RT   various human cancer cell lines.";
RL   Genes Chromosomes Cancer 42:58-67(2005).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006;
RA   Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L.,
RA   Klussmann J.P., Hafner D., Schuler P.J., Friebe-Hoffmann U.,
RA   Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H.,
RA   Balz V.;
RT   "Alterations in the p53 pathway and their association with radio- and
RT   chemosensitivity in head and neck squamous cell carcinoma.";
RL   Oral Oncol. 44:1100-1109(2008).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=20947470; DOI=10.1186/2047-783X-15-8-337; PMCID=PMC3458702;
RA   Schuler P.J., Trellakis S., Greve J., Bas M.B., Bergmann C., Bolke E.,
RA   Lehnerdt G.F., Mattheis S., Albers A.E., Brandau S., Lang S.K.,
RA   Whiteside T.L., Bier H., Hoffmann T.K.;
RT   "In vitro chemosensitivity of head and neck cancer cell lines.";
RL   Eur. J. Med. Res. 15:337-344(2010).
//
RX   PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194;
RA   Martens-de Kemp S.R., Dalm S.U., Wijnolts F.M.J., Brink A.,
RA   Honeywell R.J., Peters G.J., Braakhuis B.J.M., Brakenhoff R.H.;
RT   "DNA-bound platinum is the major determinant of cisplatin sensitivity
RT   in head and neck squamous carcinoma cells.";
RL   PLoS ONE 8:E61555-E61555(2013).
//
RX   PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528;
RA   Stoepker C., Ameziane N., van der Lelij P., Kooi I.E., Oostra A.B.,
RA   Rooimans M.A., van Mil S.E., Brink A., Dietrich R., Balk J.A.,
RA   Ylstra B., Joenje H., Feller S.M., Brakenhoff R.H.;
RT   "Defects in the Fanconi anemia pathway and chromatid cohesion in head
RT   and neck cancer.";
RL   Cancer Res. 75:3543-3553(2015).
//
RX   PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097;
RA   van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I.,
RA   Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.;
RT   "Characterization of a head and neck cancer-derived cell line panel
RT   confirms the distinct TP53-proficient copy number-silent subclass.";
RL   Oral Oncol. 98:53-61(2019).
//