ID   UM-SCC-14A
AC   CVCL_7719
SY   UM-SCC 14A; UMSCC-14A; UMSCC14A; University of Michigan-Squamous Cell Carcinoma-14A
DR   BTO; BTO:0003140
DR   cancercelllines; CVCL_7719
DR   ChEMBL-Cells; CHEMBL3707162
DR   ChEMBL-Targets; CHEMBL3707164
DR   Cosmic; 948029
DR   Cosmic; 1483458
DR   GEO; GSM3631268
DR   IARC_TP53; 11062
DR   IARC_TP53; 18879
DR   Progenetix; CVCL_7719
DR   PubChem_Cell_line; CVCL_7719
DR   Wikidata; Q54990811
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=3855324;
RX   PubMed=8679156;
RX   PubMed=8725545;
RX   PubMed=8782485;
RX   PubMed=9041179;
RX   PubMed=12884349;
RX   PubMed=15287027;
RX   PubMed=17312569;
RX   PubMed=18487078;
RX   PubMed=19760794;
RX   PubMed=20947470;
RX   PubMed=21868764;
RX   PubMed=23613873;
RX   PubMed=26122845;
RX   PubMed=29156801;
RX   PubMed=30527230;
RX   PubMed=31541927;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=18487078; PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 7133; KMT2D; Simple; p.Arg1324Thr (c.3971G>C); Zygosity=Heterozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys277_Glu286del (c.829_858del30); Zygosity=Heterozygous (PubMed=8725545; PubMed=8782485; PubMed=12884349; PubMed=15287027; PubMed=18487078; PubMed=23613873; PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Ser (c.840A>T); ClinVar=VCV000988616; Zygosity=Heterozygous (PubMed=8725545; PubMed=8782485; PubMed=12884349; PubMed=15287027; PubMed=18487078; PubMed=23613873; PubMed=31541927).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Genome sequenced (low read coverage).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
ST   Source(s): PubMed=19760794; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 11,12
ST   D18S51: 15
ST   D21S11: 29
ST   D3S1358: 15
ST   D5S818: 11,14
ST   D7S820: 9,10
ST   D8S1179: 8,13
ST   FGA: 20,21
ST   TH01: 6,8
ST   vWA: 14,18
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7720 ! UM-SCC-14B
OI   CVCL_7721 ! UM-SCC-14C
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 26
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=8679156; DOI=10.1007/BF00178278;
RA   Koldovsky P., Haas I., Bier H., Ganzer U.;
RT   "Immunohistochemical examination of 11 cell lines derived from human
RT   head and neck squamous cell carcinomas, their recurrences or
RT   metastases.";
RL   Eur. Arch. Otorhinolaryngol. 252:359-365(1995).
//
RX   PubMed=8725545; DOI=10.3109/00016489609137854;
RA   Pekkola-Heino K., Servomaa K., Kiuru A., Grenman R.;
RT   "Increased radiosensitivity is associated with p53 mutations in cell
RT   lines derived from oral cavity carcinoma.";
RL   Acta Oto-Laryngol. 116:341-344(1996).
//
RX   PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x;
RA   Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O.,
RA   Rytomaa T.;
RT   "p53 mutations associated with increased sensitivity to ionizing
RT   radiation in human head and neck cancer cell lines.";
RL   Cell Prolif. 29:219-230(1996).
//
RX   PubMed=9041179;
RA   Frank C.J., McClatchey K.D., Devaney K.O., Carey T.E.;
RT   "Evidence that loss of chromosome 18q is associated with tumor
RT   progression.";
RL   Cancer Res. 57:824-827(1997).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "P53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=15287027; DOI=10.1002/gcc.20066;
RA   Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y.,
RA   Grenman R., Fisher S.G., Carey T.E.;
RT   "Loss of chromosome arm 18q with tumor progression in head and neck
RT   squamous cancer.";
RL   Genes Chromosomes Cancer 41:145-154(2004).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006;
RA   Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L.,
RA   Klussmann J.P., Hafner D., Schuler P.J., Friebe-Hoffmann U.,
RA   Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H.,
RA   Balz V.;
RT   "Alterations in the p53 pathway and their association with radio- and
RT   chemosensitivity in head and neck squamous cell carcinoma.";
RL   Oral Oncol. 44:1100-1109(2008).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=20947470; DOI=10.1186/2047-783X-15-8-337;
RA   Schuler P.J., Trellakis S., Greve J., Bas M.B., Bergmann C., Bolke E.,
RA   Lehnerdt G.F., Mattheis S., Albers A.E., Brandau S., Lang S.K.,
RA   Whiteside T.L., Bier H., Hoffmann T.K.;
RT   "In vitro chemosensitivity of head and neck cancer cell lines.";
RL   Eur. J. Med. Res. 15:337-344(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=23613873; DOI=10.1371/journal.pone.0061555;
RA   Martens-de Kemp S.R., Dalm S.U., Wijnolts F.M.J., Brink A.,
RA   Honeywell R.J., Peters G.J., Braakhuis B.J.M., Brakenhoff R.H.;
RT   "DNA-bound platinum is the major determinant of cisplatin sensitivity
RT   in head and neck squamous carcinoma cells.";
RL   PLoS ONE 8:E61555-E61555(2013).
//
RX   PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528;
RA   Stoepker C., Ameziane N., van der Lelij P., Kooi I.E., Oostra A.B.,
RA   Rooimans M.A., van Mil S.E., Brink A., Dietrich R., Balk J.A.,
RA   Ylstra B., Joenje H., Feller S.M., Brakenhoff R.H.;
RT   "Defects in the Fanconi anemia pathway and chromatid cohesion in head
RT   and neck cancer.";
RL   Cancer Res. 75:3543-3553(2015).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30527230; DOI=10.1016/j.oraloncology.2018.10.031;
RA   Ludwig M.L., Kulkarni A., Birkeland A.C., Michmerhuizen N.L.,
RA   Foltin S.K., Mann J.E., Hoesli R.C., Devenport S.N., Jewell B.M.,
RA   Shuman A.G., Spector M.E., Carey T.E., Jiang H., Brenner J.C.;
RT   "The genomic landscape of UM-SCC oral cavity squamous cell carcinoma
RT   cell lines.";
RL   Oral Oncol. 87:144-151(2018).
//
RX   PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004;
RA   van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I.,
RA   Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.;
RT   "Characterization of a head and neck cancer-derived cell line panel
RT   confirms the distinct TP53-proficient copy number-silent subclass.";
RL   Oral Oncol. 98:53-61(2019).
//