ID   UM-SCC-10B
AC   CVCL_7714
SY   UM-SCC 10B; UMSCC-10B; UMSCC 10B; UMSCC10B; UM-SCC10B; University of Michigan-Squamous Cell Carcinoma-10B
DR   cancercelllines; CVCL_7714
DR   Cosmic; 932287
DR   Cosmic; 948026
DR   Cosmic; 2439751
DR   Cosmic; 2602594
DR   GEO; GSM3631265
DR   IARC_TP53; 18875
DR   Progenetix; CVCL_7714
DR   Wikidata; Q54990803
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1394225;
RX   PubMed=3855324;
RX   PubMed=8552396;
RX   PubMed=8679156;
RX   PubMed=12884349;
RX   PubMed=15287027;
RX   PubMed=15495191;
RX   PubMed=16020667;
RX   PubMed=16331601;
RX   PubMed=17312569;
RX   PubMed=18487078;
RX   PubMed=19760794;
RX   PubMed=20947470;
RX   PubMed=21868764;
RX   PubMed=28196595;
RX   PubMed=29156801;
RX   PubMed=31090975;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Heterozygous (PubMed=1394225; PubMed=12884349; PubMed=15287027; PubMed=16020667; PubMed=18487078).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Submental lymph node; UBERON=UBERON_0016397.
ST   Source(s): PubMed=19760794; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9
ST   D16S539: 11
ST   D18S51: 15
ST   D21S11: 30
ST   D3S1358: 17
ST   D5S818: 12,13
ST   D7S820: 9
ST   D8S1179: 13,14
ST   FGA: 22
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 19
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7713 ! UM-SCC-10A
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=1394225;
RA   Somers K.D., Merrick M.A., Lopez M.E., Incognito L.S., Schechter G.L.,
RA   Casey G.;
RT   "Frequent p53 mutations in head and neck cancer.";
RL   Cancer Res. 52:5997-6000(1992).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=8552396;
RA   Patel A.M., Incognito L.S., Schechter G.L., Wasilenko W.J.,
RA   Somers K.D.;
RT   "Amplification and expression of EMS-1 (cortactin) in head and neck
RT   squamous cell carcinoma cell lines.";
RL   Oncogene 12:31-35(1996).
//
RX   PubMed=8679156; DOI=10.1007/BF00178278;
RA   Koldovsky P., Haas I., Bier H., Ganzer U.;
RT   "Immunohistochemical examination of 11 cell lines derived from human
RT   head and neck squamous cell carcinomas, their recurrences or
RT   metastases.";
RL   Eur. Arch. Otorhinolaryngol. 252:359-365(1995).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "p53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=15287027; DOI=10.1002/gcc.20066;
RA   Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y.,
RA   Grenman R., Fisher S.G., Carey T.E.;
RT   "Loss of chromosome arm 18q with tumor progression in head and neck
RT   squamous cancer.";
RL   Genes Chromosomes Cancer 41:145-154(2004).
//
RX   PubMed=15495191; DOI=10.1002/gcc.20119;
RA   Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.;
RT   "Homozygous deletions of CDKN2A caused by alternative mechanisms in
RT   various human cancer cell lines.";
RL   Genes Chromosomes Cancer 42:58-67(2005).
//
RX   PubMed=16020667; DOI=10.1158/1535-7163.MCT-05-0081;
RA   Bauer J.A., Trask D.K., Kumar B., Los G., Castro J., Lee J.S.-J.,
RA   Chen J.-Y., Wang S.-M., Bradford C.R., Carey T.E.;
RT   "Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in
RT   head and neck cancer cells: role of wild-type p53 and Bcl-xL.";
RL   Mol. Cancer Ther. 4:1096-1104(2005).
//
RX   PubMed=16331601; DOI=10.1002/ijc.21514;
RA   Muller A., Sonkoly E., Eulert C., Gerber P.A., Kubitza R.,
RA   Schirlau K., Franken-Kunkel P., Poremba C., Snyderman C.H., Klotz L.-O.,
RA   Ruzicka T., Bier H., Zlotnik A., Whiteside T.L., Homey B.,
RA   Hoffmann T.K.;
RT   "Chemokine receptors in head and neck cancer: association with
RT   metastatic spread and regulation during chemotherapy.";
RL   Int. J. Cancer 118:2147-2157(2006).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006;
RA   Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L.,
RA   Klussmann J.P., Hafner D., Schuler P.J., Friebe-Hoffmann U.,
RA   Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H.,
RA   Balz V.;
RT   "Alterations in the p53 pathway and their association with radio- and
RT   chemosensitivity in head and neck squamous cell carcinoma.";
RL   Oral Oncol. 44:1100-1109(2008).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=20947470; DOI=10.1186/2047-783X-15-8-337; PMCID=PMC3458702;
RA   Schuler P.J., Trellakis S., Greve J., Bas M.B., Bergmann C., Bolke E.,
RA   Lehnerdt G.F., Mattheis S., Albers A.E., Brandau S., Lang S.K.,
RA   Whiteside T.L., Bier H., Hoffmann T.K.;
RT   "In vitro chemosensitivity of head and neck cancer cell lines.";
RL   Eur. J. Med. Res. 15:337-344(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=31090975; DOI=10.1002/hed.25803; PMCID=PMC6692232;
RA   Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J.,
RA   Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E.,
RA   Brenner J.C.;
RT   "The molecular landscape of the University of Michigan laryngeal
RT   squamous cell carcinoma cell line panel.";
RL   Head Neck 41:3114-3124(2019).
//