ID   UM-SCC-104
AC   CVCL_7712
SY   UMSCC-104; UMSCC104; University of Michigan-Squamous Cell Carcinoma-104
DR   cancercelllines; CVCL_7712
DR   GEO; GSM3631290
DR   Millipore; SCC072
DR   Progenetix; CVCL_7712
DR   Wikidata; Q54990797
RX   PubMed=22162267;
RX   PubMed=24201445;
RX   PubMed=26045983;
RX   PubMed=28236344;
RX   PubMed=29156801;
RX   PubMed=31541927;
RX   PubMed=32574978;
CC   Doubling time: 48 hours (PubMed=22162267); 2.6 days (PubMed=29156801).
CC   Sequence variation: Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Ile1829Val (c.5485A>G); Zygosity=Homozygous (PubMed=31541927).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Ala12Val (c.35C>T); ClinVar=VCV001494610; Zygosity=Homozygous (PubMed=31541927).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Genome sequenced (low read coverage).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
ST   Source(s): Millipore=SCC072; PubMed=22162267; PubMed=29156801
ST   Amelogenin: X (Millipore=SCC072)
ST   Amelogenin: X,Y (PubMed=22162267; PubMed=29156801)
ST   CSF1PO: 10 (Millipore=SCC072; PubMed=22162267)
ST   CSF1PO: 10,12 (PubMed=29156801)
ST   D13S317: 8 (Millipore=SCC072)
ST   D13S317: 8,9 (PubMed=22162267; PubMed=29156801)
ST   D16S539: 9 (Millipore=SCC072; PubMed=22162267)
ST   D16S539: 9,13 (PubMed=29156801)
ST   D18S51: 13,14
ST   D19S433: 14,15.2
ST   D21S11: 30,32.2
ST   D2S1338: 17,20
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 10
ST   D8S1179: 9,13
ST   FGA: 24
ST   Penta D: 9,12
ST   Penta E: 13
ST   TH01: 6
ST   TPOX: 9,10
ST   vWA: 16,17
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 24
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RX   PubMed=22162267; DOI=10.1002/hed.21962; PMCID=PMC3369005;
RA   Tang A.L., Hauff S.J., Owen J.H., Graham M.P., Czerwinski M.J.,
RA   Park J.J., Walline H.M., Papagerakis S., Stoerker J., McHugh J.B.,
RA   Chepeha D.B., Bradford C.R., Carey T.E., Prince M.E.P.;
RT   "UM-SCC-104: a new human papillomavirus-16-positive cancer stem
RT   cell-containing head and neck squamous cell carcinoma cell line.";
RL   Head Neck 34:1480-1491(2012).
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RX   PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410;
RA   Akagi K., Li J.-F., Broutian T.R., Padilla-Nash H.M., Xiao W.-H.,
RA   Jiang B., Rocco J.W., Teknos T.N., Kumar B., Wangsa D., He D., Ried T.,
RA   Symer D.E., Gillison M.L.;
RT   "Genome-wide analysis of HPV integration in human cancers reveals
RT   recurrent, focal genomic instability.";
RL   Genome Res. 24:185-199(2014).
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RX   PubMed=26045983; PMCID=PMC4449432;
RA   Ziemann F., Arenz A., Preising S., Wittekindt C., Klussmann J.P.,
RA   Engenhart-Cabillic R., Wittig A.;
RT   "Increased sensitivity of HPV-positive head and neck cancer cell lines
RT   to X-irradiation +/- cisplatin due to decreased expression of E6 and
RT   E7 oncoproteins and enhanced apoptosis.";
RL   Am. J. Cancer Res. 5:1017-1031(2015).
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RX   PubMed=28236344; DOI=10.1002/hed.24729; PMCID=PMC5392184;
RA   Walline H.M., Goudsmit C.M., McHugh J.B., Tang A.L., Owen J.H.,
RA   Teh B.T., McKean E.L., Glover T.W., Graham M.P., Prince M.E.P.,
RA   Chepeha D.B., Chinn S.B., Ferris R.L., Gollin S.M., Hoffmann T.K.,
RA   Bier H., Brakenhoff R.H., Bradford C.R., Carey T.E.;
RG   University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program;
RT   "Integration of high-risk human papillomavirus into cellular
RT   cancer-related genes in head and neck cancer cell lines.";
RL   Head Neck 39:840-852(2017).
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RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
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RX   PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097;
RA   van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I.,
RA   Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.;
RT   "Characterization of a head and neck cancer-derived cell line panel
RT   confirms the distinct TP53-proficient copy number-silent subclass.";
RL   Oral Oncol. 98:53-61(2019).
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RX   PubMed=32574978; DOI=10.1016/j.tranon.2020.100808; PMCID=PMC7317296;
RA   Nair T.S., Thomas T.B., Yang L., Kakaraparthi B.N., Morris A.C.,
RA   Clark A.M., Campredon L.P., Brouwer A.F., Eisenberg M.C., Meza R.,
RA   Carey T.E.;
RT   "Characteristics of head and neck squamous cell carcinoma cell lines
RT   reflect human tumor biology independent of primary etiologies and HPV
RT   status.";
RL   Transl. Oncol. 13:100808.1-100808.9(2020).
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