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Cellosaurus HEI193 (CVCL_7670)

[Text version]
Cell line name HEI193
Synonyms HEI-193; HEI 193; House Ear Institute 193
Accession CVCL_7670
Resource Identification Initiative To cite this cell line use: HEI193 (RRID:CVCL_7670)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-4544.
Doubling time: 12 hours (PubMed=17304235).
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Peripheral nervous system, vestibular nerve; UBERON=UBERON_0003723.
Cell type: Schwann cell; CL=CL_0002573.
Sequence variations
  • Mutation; HGNC; 7773; NF2; Simple; c.1575-1G>A; ClinVar=VCV001285395; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=11836557).
Disease Neurofibromatosis type 2 (NCIt: C3274)
Vestibular schwannoma (NCIt: C3276)
Neurofibromatosis type 2 (ORDO: Orphanet_637)
Vestibular schwannoma (ORDO: Orphanet_252175)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Transformed cell line
Publications

PubMed=11836557; DOI=10.3892/ijo.20.3.475
Hung G., Li X.-K., Faudoa R., Xeu Z., Kluwe L., Rhim J.S., Slattery W., Lim D.J.
Establishment and characterization of a schwannoma cell line from a patient with neurofibromatosis 2.
Int. J. Oncol. 20:475-482(2002)

PubMed=17304235; DOI=10.1038/sj.cgt.7701037
Prabhakar S., Messerli S.M., Stemmer-Rachamimov A.O., Liu T.-C., Rabkin S.D., Martuza R.L., Breakefield X.O.
Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta.
Cancer Gene Ther. 14:460-467(2007)

PubMed=17868749; DOI=10.1016/j.mrfmmm.2007.07.015
Lepont P., Stickney J.T., Foster L.A., Meng J.-J., Hennigan R.F., Ip W.
Point mutation in the NF2 gene of HEI-193 human schwannoma cells results in the expression of a merlin isoform with attenuated growth suppressive activity.
Mutat. Res. 637:142-151(2008)

PubMed=28469964
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

Cross-references
Anatomy/cell type resources BTO; BTO:0005037
Encyclopedic resources Wikidata; Q54882275
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number15