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Cellosaurus AT5BI (CVCL_7441)

[Text version]
Cell line name AT5BI
Synonyms AT 5BI; Ataxia Telangiectasia 5 BIrmingham; GM05823; GM5823; GM05823A; GM5823A; GM05823C
Accession CVCL_7441
Resource Identification Initiative To cite this cell line use: AT5BI (RRID:CVCL_7441)
Comments Misspelling: AT5B1; Note=Occasionally.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_7442 (AT5BIVA)CVCL_VL10 (GM05823+hTERT)
Sex of cell Male
Age at sampling 18Y
Category Finite cell line
Publications

PubMed=450131; DOI=10.1038/279797a0
Day R.S. 3rd, Ziolkowski C.H.J.
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.
Nature 279:797-799(1979)

PubMed=7471105
Weichselbaum R.R., Nove J., Little J.B.
X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders.
Cancer Res. 40:920-925(1980)

PubMed=7471106
Arlett C.F., Harcourt S.A.
Survey of radiosensitivity in a variety of human cell strains.
Cancer Res. 40:926-932(1980)

PubMed=11219864; DOI=10.1093/carcin/1.9.745
Arlett C.F., Harcourt S.A., Lehmann A.R., Stevens S., Ferguson-Smith M.A., Morley W.N.
Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation.
Carcinogenesis 1:745-751(1980)

PubMed=6810166; DOI=10.1016/0027-5107(82)90299-8
Barfknecht T.R., Little J.B.
Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents.
Mutat. Res. 94:369-382(1982)

PubMed=7067035; DOI=10.1093/carcin/3.1.33
Teo I.A., Arlett C.F.
The response of a variety of human fibroblast cell strains to the lethal effects of alkylating agents.
Carcinogenesis 3:33-37(1982)

PubMed=6600729; DOI=10.1080/09553008314550171
Arlett C.F., Priestley A.
Defective recovery from potentially lethal damage in some human fibroblast cell strains.
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 43:157-167(1983)

PubMed=6843573; DOI=10.1016/0027-5107(83)90054-4
Nagasawa H., Little J.B.
Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts.
Mutat. Res. 109:297-308(1983)

PubMed=6442144; DOI=10.1007/978-1-4684-4892-4_20
Nagasawa H., Little F.F., Burke M.J., McCone E.F., Targovnik H.S., Chan G.L., Little J.B.
Study of basal cell nevus syndrome fibroblasts after treatment with DNA-damaging agents.
Basic Life Sci. 29:775-785(1984)

PubMed=2903889; DOI=10.1080/09553008814552321
Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=2973075; DOI=10.2307/3577479
Fertil B., Deschavanne P.J., Debieu D., Malaise E.-P.
Correlation between PLD repair capacity and the survival curve of human fibroblasts in exponential growth phase: analysis in terms of several parameters.
Radiat. Res. 116:74-88(1988)

PubMed=3337113; PMCID=PMC1715319
Jaspers N.G.J., Taalman R.D.F.M., Baan C.C.
Patients with an inherited syndrome characterized by immunodeficiency, microcephaly, and chromosomal instability: genetic relationship to ataxia telangiectasia.
Am. J. Hum. Genet. 42:66-73(1988)

CLPUB00447
Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=7792600; DOI=10.1126/science.7792600
Savitsky K., Bar-Shira A., Gilad S., Rotman G., Ziv Y., Vanagaite L., Tagle D.A., Smith S., Uziel T., Sfez S., Ashkenazi M., Pecker I., Frydman M., Harnik R., Patanjali S.R., Simmons A.D., Clines G.A., Sartiel A., Gatti R.A., Chessa L., Sanal O., Lavin M.F., Jaspers N.G.J., Taylor A.M.R., Arlett C.F., Miki T., Weissman S.M., Lovett M., Collins F.S., Shiloh Y.
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Science 268:1749-1753(1995)

PubMed=8808599; PMCID=PMC1914811
Wright J., Teraoka S., Onengut S., Tolun A., Gatti R.A., Ochs H.D., Concannon P.
A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.
Am. J. Hum. Genet. 59:839-846(1996)

PubMed=8845835; DOI=10.1093/hmg/5.4.433
Gilad S., Khosravi R., Shkedy D., Uziel T., Ziv Y., Savitsky K., Rotman G., Smith S., Chessa L., Jorgensen T.J., Harnik R., Frydman M., Sanal O., Portnoi S., Goldwicz Z., Jaspers N.G.J., Gatti R.A., Lenoir G.M., Lavin M.F., Tatsumi K., Wegner R.-D., Shiloh Y., Bar-Shira A.
Predominance of null mutations in ataxia-telangiectasia.
Hum. Mol. Genet. 5:433-439(1996)

PubMed=10987302
Girard P.-M., Foray N., Stumm M., Waugh A.P.W., Riballo E., Maser R.S., Phillips W.P., Petrini J.H.J., Arlett C.F., Jeggo P.A.
Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects.
Cancer Res. 60:4881-4888(2000)

PubMed=11313956; DOI=10.1038/sj.onc.1204072
Wood L.D., Halvorsen T.L., Dhar S., Baur J.A., Pandita R.K., Wright W.E., Hande M.P., Calaf G., Hei T.K., Levine F., Shay J.W., Wang J.J.Y., Pandita T.K.
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.
Oncogene 20:278-288(2001)

PubMed=12082606; DOI=10.1038/sj.onc.1205596
Girard P.-M., Riballo E., Begg A.C., Waugh A.P.W., Jeggo P.A.
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Oncogene 21:4191-4199(2002)

PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029
Riballo E., Kuhne M., Rief N., Doherty A.J., Smith G.C.M., Recio M.-J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A.R., Jeggo P.A., Lobrich M.
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Mol. Cell 16:715-724(2004)

PubMed=18079351; DOI=10.1259/bjr/27072321
Arlett C.F., Green M.H.L., Rogers P.B., Lehmann A.R., Plowman P.N.
Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
Br. J. Radiol. 81:51-58(2008)

PubMed=19896956; DOI=10.1016/j.mrfmmm.2009.10.013
Wilson P.F., Nham P.B., Urbin S.S., Hinz J.M., Jones I.M., Thompson L.H.
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation.
Mutat. Res. 683:91-97(2010)

Cross-references
Cell line collections (Providers) Coriell; GM05823
JCRB; KURB1822
Cell line databases/resources CLO; CLO_0024679
Encyclopedic resources Wikidata; Q54750947
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number26