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Cellosaurus XP30RO (CVCL_7395)

[Text version]
Cell line name XP30RO
Synonyms XP3ORO; XP-V XP30RO; XP-V (XP30RO); GM03617; GM03617A; GM3617; IMG-991 XP3ORO; IMG-991
Accession CVCL_7395
Secondary accession CVCL_G334; CVCL_IM58
Resource Identification Initiative To cite this cell line use: XP30RO (RRID:CVCL_7395)
Comments Population: Lebanese.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 9181; POLH; Simple; p.Ala35fs (c.104_116del); Zygosity=Homozygous (PubMed=10385124; PubMed=10398605).
Disease Xeroderma pigmentosum variant type (NCIt: C141367)
Xeroderma pigmentosum variant (ORDO: Orphanet_90342)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WY39 (TR30-9)
Sex of cell Male
Age at sampling 30Y
Category Finite cell line
Publications

PubMed=4778857; DOI=10.1016/0027-5107(73)90062-6
Kleijer W.J., de Weerd-Kastelein E.A., Sluyter M.L., Keijzer W., de Wit J., Bootsma D.
UV-induced DNA repair synthesis in cells of patients with different forms of xeroderma pigmentosum and of heterozygotes.
Mutat. Res. 20:417-428(1973)

PubMed=1214825; DOI=10.1016/0027-5107(75)90209-2
Arlett C.F., Harcourt S.A., Broughton B.C.
The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet-light irradiation.
Mutat. Res. 33:341-346(1975)

PubMed=837385
Lehmann A.R., Kirk-Bell S., Arlett C.F., Harcourt S.A., de Weerd-Kastelein E.A., Keijzer W., Hall-Smith P.
Repair of ultraviolet light damage in a variety of human fibroblast cell strains.
Cancer Res. 37:904-910(1977)

PubMed=7471106
Arlett C.F., Harcourt S.A.
Survey of radiosensitivity in a variety of human cell strains.
Cancer Res. 40:926-932(1980)

PubMed=6947227; DOI=10.1073/pnas.78.10.6236; PMCID=PMC349013
Miskin R., Ben-Ishai R.
Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts.
Proc. Natl. Acad. Sci. U.S.A. 78:6236-6240(1981)

PubMed=7326997; DOI=10.1159/000131646
Cleaver J.E., Greene A.E., Coriell L.L., Mulivor R.A.
Xeroderma pigmentosum variants.
Cytogenet. Cell Genet. 31:188-192(1981)

PubMed=7067035; DOI=10.1093/carcin/3.1.33
Teo I.A., Arlett C.F.
The response of a variety of human fibroblast cell strains to the lethal effects of alkylating agents.
Carcinogenesis 3:33-37(1982)

PubMed=6096694; DOI=10.1128/mcb.4.11.2341-2346.1984; PMCID=PMC369063
Abrahams P.J., Huitema B.A., van der Eb A.J.
Enhanced reactivation and enhanced mutagenesis of herpes simplex virus in normal human and xeroderma pigmentosum cells.
Mol. Cell. Biol. 4:2341-2346(1984)

CLPUB00447
Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=7565859; DOI=10.1016/0921-8777(95)00015-C
Volpe J.P.G., Cleaver J.E.
Xeroderma pigmentosum variant cells are resistant to immortalization.
Mutat. Res. 337:111-117(1995)

PubMed=10022907; DOI=10.1128/mcb.19.3.2206; PMCID=PMC84013
Cordonnier A.M., Lehmann A.R., Fuchs R.P.P.
Impaired translesion synthesis in xeroderma pigmentosum variant extracts.
Mol. Cell. Biol. 19:2206-2211(1999)

PubMed=10385124; DOI=10.1038/21447
Masutani C., Kusumoto R., Yamada A., Dohmae N., Yokoi M., Yuasa M., Araki M., Iwai S., Takio K., Hanaoka F.
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.
Nature 399:700-704(1999)

PubMed=10398605; DOI=10.1126/science.285.5425.263
Johnson R.E., Kondratick C.M., Prakash S., Prakash L.
hRAD30 mutations in the variant form of xeroderma pigmentosum.
Science 285:263-265(1999)

PubMed=11773631; DOI=10.1073/pnas.022473899; PMCID=PMC117388
Broughton B.C., Cordonnier A.M., Kleijer W.J., Jaspers N.G.J., Fawcett H., Raams A., Garritsen V.H., Stary A., Avril M.-F., Boudsocq F., Masutani C., Hanaoka F., Fuchs R.P.P., Sarasin A., Lehmann A.R.
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.
Proc. Natl. Acad. Sci. U.S.A. 99:815-820(2002)

PubMed=16520097; DOI=10.1016/j.dnarep.2006.01.008
Cruet-Hennequart S., Coyne S., Glynn M.T., Oakley G.G., Carty M.P.
UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.
DNA Repair 5:491-504(2006)

Cross-references
Cell line collections (Providers) Coriell; GM03617
Cell line databases/resources CLO; CLO_0006939
CLO; CLO_0017188
CLDB; cl2871
Anatomy/cell type resources BTO; BTO:0004753
Encyclopedic resources Wikidata; Q54994917
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number25