ID   ECC-1
AC   CVCL_7260
SY   ECC1; EnCa1
DR   BTO; BTO:0005365
DR   CLO; CLO_0037231
DR   EFO; EFO_0005231
DR   ATCC; CRL-2923
DR   BioSample; SAMN03151801
DR   BioSample; SAMN03472871
DR   cancercelllines; CVCL_7260
DR   Cosmic; 1102375
DR   Cosmic; 1576451
DR   Cosmic; 1622895
DR   Cosmic; 2030461
DR   ENCODE; ENCBS034DOC
DR   ENCODE; ENCBS159ITB
DR   ENCODE; ENCBS222DWG
DR   ENCODE; ENCBS312UTV
DR   ENCODE; ENCBS336PJO
DR   ENCODE; ENCBS347ANJ
DR   ENCODE; ENCBS624SHM
DR   ENCODE; ENCBS670ZEX
DR   ENCODE; ENCBS731RSG
DR   ENCODE; ENCBS743VIZ
DR   ENCODE; ENCBS758FSP
DR   ENCODE; ENCBS767JJY
DR   ENCODE; ENCBS862NRL
DR   ENCODE; ENCBS896YZO
DR   GEO; GSM843495
DR   GEO; GSM843496
DR   GEO; GSM923422
DR   GEO; GSM923423
DR   GEO; GSM923426
DR   GEO; GSM923427
DR   GEO; GSM1008597
DR   GEO; GSM1008574
DR   Lonza; 1319
DR   Wikidata; Q54831921
RX   PubMed=10478797;
RX   PubMed=16707768;
RX   PubMed=20218740;
RX   PubMed=22710073;
RX   PubMed=23325432;
RX   PubMed=25877200;
RX   PubMed=33174010;
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/ECC1_Myers_protocol.pdf
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a Ishikawa 3-H-12 derivative (PubMed=22710073).
CC   Part of: ENCODE project common cell types; tier 3.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00460.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Array-based CGH.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: ATCC; CRL-2923; true.
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
ST   Source(s): ATCC; PubMed=22710073; PubMed=25877200; PubMed=33174010
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9,12
ST   D16S539: 9
ST   D18S51: 12,19
ST   D19S433: 12.2,14
ST   D21S11: 28
ST   D2S1338: 20
ST   D3S1358: 16,17
ST   D5S818: 10,11
ST   D7S820: 9,10
ST   D8S1179: 13,16
ST   FGA: 21
ST   Penta D: 10,11
ST   Penta E: 11,19.1
ST   TH01: 9,10
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C7359; Endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D199 ! Ishikawa 3-H-12
SX   Female
AG   39Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
//
RX   PubMed=10478797; DOI=10.1007/s11626-999-0025-5;
RA   Ricci M.S., Toscano D.G., Toscano W.A. Jr.;
RT   "ECC-1 human endometrial cells as a model system to study dioxin
RT   disruption of steroid hormone function.";
RL   In Vitro Cell. Dev. Biol. Anim. 35:183-189(1999).
//
RX   PubMed=16707768; DOI=10.1095/biolreprod.106.051870;
RA   Mo B., Vendrov A.E., Palomino W.A., DuPont B.R., Apparao K.B.C.,
RA   Lessey B.A.;
RT   "ECC-1 cells: a well-differentiated steroid-responsive endometrial
RT   cell line with characteristics of luminal epithelium.";
RL   Biol. Reprod. 75:387-394(2006).
//
RX   PubMed=20218740; DOI=10.1177/153303461000900207;
RA   Wang Y.-M., Yang D., Cogdell D., Hu L.-M., Xue F.-X., Broaddus R.,
RA   Zhang W.;
RT   "Genomic characterization of gene copy-number aberrations in
RT   endometrial carcinoma cell lines derived from endometrioid-type
RT   endometrial adenocarcinoma.";
RL   Technol. Cancer Res. Treat. 9:179-189(2010).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017;
RA   Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K.,
RA   Lessey B.A., Jordan V.C., Bradford A.P.;
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=23325432; DOI=10.1101/gr.147942.112;
RA   Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E.,
RA   Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A.,
RA   Crawford G.E., Absher D.M., Wold B.J., Myers R.M.;
RT   "Dynamic DNA methylation across diverse human cell lines and
RT   tissues.";
RL   Genome Res. 23:555-567(2013).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=33174010; DOI=10.3892/ijo.2020.5139;
RA   Devor E.J., Gonzalez-Bosquet J., Thiel K.W., Leslie K.K.;
RT   "Genomic characterization of five commonly used endometrial cancer
RT   cell lines.";
RL   Int. J. Oncol. 57:1348-1357(2020).
//