Cell line name |
A2780-DX3 |
Synonyms |
A2780/DX3; A2780 DX3; DX3 |
Accession |
CVCL_7225 |
Resource Identification Initiative |
To cite this cell line use: A2780-DX3 (RRID:CVCL_7225) |
Comments |
Population: African American. Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin). Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
|
Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979) Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_4T96 (A2780-DX2) Children:
|
Sex of cell |
Female |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=2598402; DOI=10.1007/BF00692343 Alaoui-Jamali M.A., Yin M.-B., Mazzoni A., Bankusli I., Rustum Y.M. Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933. Cancer Chemother. Pharmacol. 25:77-83(1989) PubMed=2751261 Mazzoni A., Trave F., Canti G., Franco P. Effect of the tiapamil analog RO11-2933 on cellular sensitivity to antitumor drugs in sensitive and multidrug resistant human ovarian cancer cells. Anticancer Res. 9:367-371(1989) PubMed=8012063 Cimoli G., Valenti M., Parodi S., Mazzoni A., De Sessa F., Conte P., Russo P. Reversal of 'atypical'-multidrug resistance by recombinant human tumor necrosis factor in the human ovarian cancer cell line A2780-DX3. Oncol. Res. 5:311-323(1993) PubMed=7713987; DOI=10.1007/BF01198097 Cimoli G., Valenti M., Noviello E., Parodi S., Mazzoni A., Rovini E., De Sessa F., Russo P. 'Atypical' multidrug resistance in human ovarian cancer cell line A2780 selected for resistance to doxorubicin (A2780 DX3). J. Cancer Res. Clin. Oncol. 121:155-163(1995) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_7225
|
Anatomy/cell type resources |
BTO; BTO_0002642
|
Encyclopedic resources |
Wikidata; Q54606570
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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