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Cellosaurus A2780/100 (CVCL_7224)

[Text version]
Cell line name A2780/100
Synonyms A2780(100)
Accession CVCL_7224
Resource Identification Initiative To cite this cell line use: A2780/100 (RRID:CVCL_7224)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_28830; Chlorambucil (CBL; Leukeran).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=10413308; DOI=10.1016/S0006-2952(99)00142-2
Horton J.K., Roy G., Piper J.T., Van Houten B., Awasthi Y.C., Mitra S., Alaoui-Jamali M.A., Boldogh I., Singhal S.S.
Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu.
Biochem. Pharmacol. 58:693-702(1999)

PubMed=10644989; DOI=10.1038/sj.onc.1203318
Roy G., Horton J.K., Roy R., Denning T., Mitra S., Boldogh I.
Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins.
Oncogene 19:141-150(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7224
Anatomy/cell type resources BTO; BTO_0003207
Encyclopedic resources Wikidata; Q54606583
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number17