ID   DEV [Human lymphoma]
AC   CVCL_7187
DR   Cosmic; 1293254
DR   GEO; GSM1897960
DR   Lonza; 268
DR   Wikidata; Q54831018
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2690233;
RX   PubMed=3881158;
RX   PubMed=12581897;
RX   PubMed=19648161;
RX   PubMed=27998726;
RX   PubMed=29533902;
CC   Problematic cell line: Misclassified. Originally thought to be a Hodgkin lymphoma cell line, but seems to be from a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).
CC   Doubling time: ~3 days (PubMed=3881158).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C7258; Nodular lymphocyte predominant Hodgkin lymphoma
DI   ORDO; Orphanet_86893; Nodular lymphocyte predominant Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 17
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RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5;
RA   Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E.,
RA   Tesch H., Fonatsch C., Stein H., Diehl V.;
RT   "Biology of Hodgkin cell lines.";
RL   Recent Results Cancer Res. 117:53-61(1989).
//
RX   PubMed=3881158; DOI=10.1002/1097-0142(19850215)55:4<683::AID-CNCR2820550402>3.0.CO;2-O;
RA   Poppema S., de Jong B., Atmosoerodjo J., Idenburg V., Visser L.,
RA   de Leij L.F.M.H.;
RT   "Morphologic, immunologic, enzymehistochemical and chromosomal
RT   analysis of a cell line derived from Hodgkin's disease. Evidence for a
RT   B-cell origin of Sternberg-Reed cells.";
RL   Cancer 55:683-690(1985).
//
RX   PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8;
RA   Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C.,
RA   Lagercrantz S., Enblad G.;
RT   "Molecular cytogenetic characterization of four commonly used cell
RT   lines derived from Hodgkin lymphoma.";
RL   Cancer Genet. Cytogenet. 141:43-48(2003).
//
RX   PubMed=19648161; DOI=10.3324/haematol.2009.010157;
RA   Schumacher M.A., Schmitz R., Brune V., Tiacci E., Doring C.,
RA   Hansmann M.-L., Siebert R., Kuppers R.;
RT   "Mutations in the genes coding for the NF-kappaB regulating factors
RT   IkappaBalpha and A20 are uncommon in nodular lymphocyte-predominant
RT   Hodgkin's lymphoma.";
RL   Haematologica 95:153-157(2010).
//
RX   PubMed=27998726; DOI=10.1016/j.ajpath.2016.10.007;
RA   Fromm J.R., Thomas A., Wood B.L.;
RT   "Characterization and purification of neoplastic cells of nodular
RT   lymphocyte predominant Hodgkin lymphoma from lymph nodes by flow
RT   cytometry and flow cytometric cell sorting.";
RL   Am. J. Pathol. 187:304-317(2017).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler H.G., Pommerenke C., Eberth S., Nagel S.;
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//