Cellosaurus cell line TC-253 (CVCL

Cellosaurus TC-253 (CVCL_7150)

[Text version]

Cell line name

TC-253

Accession

CVCL_7150

Resource Identification Initiative

To cite this cell line use: TC-253 (RRID:CVCL_7150)

Comments

Omics: Transcriptome analysis by RNAseq.

Sequence variations

Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 3 fusion (Ex10/Ex6) (PubMed=25010205).
Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Asn842fs; Zygosity=Unspecified (PubMed=25010205).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=25010205).

Disease

Alveolar rhabdomyosarcoma (NCIt: C3749)
Alveolar rhabdomyosarcoma (ORDO: Orphanet_99756)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

25Y

Category

Cancer cell line

STR profile

Source(s): PubMed=25010205

Markers:

Amelogenin	X
CSF1PO	11,13
D2S1338	17,20
D3S1358	16,17
D5S818	11,12
D7S820	11
D8S1179	13,14
D13S317	8,10
D16S539	12
D18S51	13,18
D19S433	13
D21S11	29
FGA	24
TH01	7,8
TPOX	8,10
vWA	18,19

Publications

PubMed=7882340
Sorensen P.H.B., Shimada H., Liu X.F., Lim J.F., Thomas G., Triche T.J.
Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.
Cancer Res. 55:1385-1392(1995)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_7150

Encyclopedic resources

Wikidata; Q54971808

Polymorphism and mutation databases

Cosmic; 1091070
Cosmic; 2228243

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number