ID   SCMC-L10
AC   CVCL_7126
SY   L10; Saitama Children's Medical Center-Leukemia 10
DR   BTO; BTO_0004949
DR   Cosmic; 710460
DR   Cosmic; 996294
DR   Cosmic; 998689
DR   Cosmic; 1037740
DR   IARC_TP53; 3950
DR   Wikidata; Q54952453
RX   CelloPub=CLPUB00111;
RX   PubMed=7727782;
RX   PubMed=8139288;
RX   PubMed=10233379;
RX   PubMed=14504097;
RX   PubMed=29786757;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.627_632AAACAC>CCCACACGCA; Zygosity=Unspecified (PubMed=7727782).
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Children
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 17
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RX   CelloPub=CLPUB00111;
RA   Hayashi Y., Kawamura M., Kobayashi S., Moriwaki K., Kobayashi M.,
RA   Bessho F., Hanada R., Yamamoto K., Mori T., Nakazawa S., Yaginuma Y.,
RA   Honma Y., Hozumi M.;
RT   "Establishment and characterization of cell lines derived from
RT   childhood leukemias.";
RL   Int. J. Hematol. 57 Suppl. 1:124-124(1993).
//
RX   PubMed=7727782; DOI=10.1182/blood.V85.9.2546.bloodjournal8592546;
RA   Kawamura M., Kikuchi A., Kobayashi S., Hanada R., Yamamoto K.,
RA   Horibe K., Shikano T., Ueda K., Hayashi K., Sekiya T., Hayashi Y.;
RT   "Mutations of the p53 and ras genes in childhood t(1;19)-acute
RT   lymphoblastic leukemia.";
RL   Blood 85:2546-2552(1995).
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RX   PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x;
RA   Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K.,
RA   Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.;
RT   "Effects of herbimycin A and its derivatives on growth and
RT   differentiation of Ph1-positive acute lymphoid leukemia cell lines.";
RL   Leuk. Res. 18:221-228(1994).
//
RX   PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x;
RA   Xu F., Taki T., Yang H.W., Hanada R., Hongo T., Ohnishi H.,
RA   Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.;
RT   "Tandem duplication of the FLT3 gene is found in acute lymphoblastic
RT   leukaemia as well as acute myeloid leukaemia but not in
RT   myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in
RT   children.";
RL   Br. J. Haematol. 105:155-162(1999).
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RX   PubMed=14504097; DOI=10.1182/blood-2003-02-0418;
RA   Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R.,
RA   Tsuchida M., Sugita K., Ida K., Hayashi Y.;
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//