ID   SCMC-L1
AC   CVCL_7125
AS   CVCL_G317
SY   SCMC-L-1; SCMCL-L1; Saitama Children's Medical Center-Leukemia 1
DR   Cosmic; 998688
DR   Cosmic; 1037738
DR   Wikidata; Q54952452
RX   CelloPub=CLPUB00110;
RX   CelloPub=CLPUB00111;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7647001;
RX   PubMed=10233379;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=14671638;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (PubMed=14671638).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168).
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged
DI   ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   4M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
//
RX   CelloPub=CLPUB00110;
RA   Hayashi Y., Hanada R., Moriwaki K., Yamamoto K., Imaizumi S.,
RA   Hirata A., Nishida T.;
RT   "Establishment and characterization of cell lines derived from
RT   malignant tumors in children.";
RL   Saitama Shoni Iryo Senta Igaku-shi 8:16-23(1991).
//
RX   CelloPub=CLPUB00111;
RA   Hayashi Y., Kawamura M., Kobayashi S., Moriwaki K., Kobayashi M.,
RA   Bessho F., Hanada R., Yamamoto K., Mori T., Nakazawa S., Yaginuma Y.,
RA   Honma Y., Hozumi M.;
RT   "Establishment and characterization of cell lines derived from
RT   childhood leukemias.";
RL   Int. J. Hematol. 57 Suppl. 1:124-124(1993).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=7647001; DOI=10.1111/j.1365-2141.1995.tb05591.x;
RA   Ito E., Kasai M., Hayashi Y., Toki T., Arai K., Yokoyama S., Kato K.,
RA   Tachibana N., Yamamoto M., Yokoyama M.;
RT   "Expression of erythroid-specific genes in acute megakaryoblastic
RT   leukaemia and transient myeloproliferative disorder in Down's
RT   syndrome.";
RL   Br. J. Haematol. 90:607-614(1995).
//
RX   PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x;
RA   Xu F., Taki T., Yang H.W., Hanada R., Hongo T., Ohnishi H.,
RA   Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.;
RT   "Tandem duplication of the FLT3 gene is found in acute lymphoblastic
RT   leukaemia as well as acute myeloid leukaemia but not in
RT   myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in
RT   children.";
RL   Br. J. Haematol. 105:155-162(1999).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Corrigendum to: Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24
RT   (2000), 255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//