Cellosaurus cell line MB-02 (CVCL

Cellosaurus MB-02 (CVCL_7075)

Cross-references
Cell line name	MB-02
Synonyms	MB02; MBO2
Accession	CVCL_7075
Resource Identification Initiative	To cite this cell line use: MB-02 (RRID:CVCL_7075)
Comments	Problematic cell line: Partially contaminated. Some stocks were contaminated by HU-3 (PubMed=10516762). Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00165. Characteristics: CSF2 dependent. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (PubMed=16408098).
Disease	Adult acute megakaryoblastic leukemia (NCIt: C7965) Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	70Y
Category	Cancer cell line
Web pages	https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=1954374; DOI=10.1182/blood.V78.11.2860.2860 Morgan D.A., Gumucio D.L., Brodsky I. Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02. Blood 78:2860-2871(1991) PubMed=9096695; DOI=10.1038/sj.leu.2400621 Drexler H.G., Zaborski M., Quentmeier H. Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines. Leukemia 11:541-551(1997) PubMed=10516762; DOI=10.1038/sj.leu.2401510 Drexler H.G., Dirks W.G., MacLeod R.A.F. False human hematopoietic cell lines: cross-contaminations and misinterpretations. Leukemia 13:1601-1607(1999) DOI=10.1016/B978-0-12-221970-2.50457-5 Drexler H.G. The leukemia-lymphoma cell line factsbook. (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001) PubMed=16408098; DOI=10.1038/sj.leu.2404081 Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G. JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders. Leukemia 20:471-476(2006)
Cell line databases/resources	cancercelllines; CVCL_7075
Anatomy/cell type resources	BTO; BTO_0004767
Encyclopedic resources	Wikidata; Q54904079
Gene expression databases	GEO; GSM743417
Polymorphism and mutation databases	Cosmic; 787449 Cosmic; 924045 Cosmic; 975267 Cosmic; 1012052 Cosmic; 1012084 Cosmic; 1281325 Cosmic; 1465957 Cosmic; 2306216
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	22