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Cellosaurus Lec15.1 (CVCL_7054)

[Text version]
Cell line name Lec15.1
Synonyms CHO Lec15.1; Lec15.1 CHO; B4-2-1; B421
Accession CVCL_7054
Secondary accession CVCL_DD08
Resource Identification Initiative To cite this cell line use: Lec15.1 (RRID:CVCL_7054)
Comments Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; UniProtKB; Q9Z1P1; Dpm2; Simple; p.Gly10Glu (c.29G>A); Zygosity=Unspecified (PubMed=14680801).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_DD06 (N211-1-8)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6270122; DOI=10.1016/S0021-9258(19)68668-0
Robbins A.R., Myerowitz R., Youle R.J., Murray G.J., Neville D.M. Jr.
The mannose 6-phosphate receptor of Chinese hamster ovary cells Isolation of mutants with altered receptors.
J. Biol. Chem. 256:10618-10622(1981)

PubMed=2105319; DOI=10.1016/S0021-9258(19)39975-2
Zeng Y.-C., Lehrman M.A.
A block at Man5GlcNAc2-pyrophosphoryldolichol in intact but not disrupted castanospermine and swainsonine-resistant Chinese hamster ovary cells.
J. Biol. Chem. 265:2296-2305(1990)

PubMed=2267628; DOI=10.1007/BF01233094
Beck P.J., Gething M.-J., Sambrook J.F., Lehrman M.A.
Complementing mutant alleles define three loci involved in mannosylation of Man5-GlcNAc2-P-P-dolichol in Chinese hamster ovary cells.
Somat. Cell Mol. Genet. 16:539-548(1990)

PubMed=1986234; DOI=10.1128/mcb.11.1.391-400.1991; PMCID=PMC359638
Singh N., Tartakoff A.M.
Two different mutants blocked in synthesis of dolichol-phosphoryl-mannose do not add glycophospholipid anchors to membrane proteins: quantitative correction of the phenotype of a CHO cell mutant with tunicamycin.
Mol. Cell. Biol. 11:391-400(1991)

PubMed=9753618; DOI=10.1006/bbrc.1998.9304
Walker B.K., Lei H., Krag S.S.
A functional link between N-linked glycosylation and apoptosis in Chinese hamster ovary cells.
Biochem. Biophys. Res. Commun. 250:264-270(1998)

PubMed=14680801; DOI=10.1016/j.bbrc.2003.10.152
Pu L.-X., Scocca J.R., Walker B.K., Krag S.S.
A single point mutation resulting in an adversely reduced expression of DPM2 in the Lec15.1 cells.
Biochem. Biophys. Res. Commun. 312:555-561(2003)

PubMed=20331963; DOI=10.1016/j.bbrc.2010.03.117; PMCID=PMC2887678
Jones M.B., Tomiya N., Betenbaugh M.J., Krag S.S.
Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells.
Biochem. Biophys. Res. Commun. 395:36-41(2010)

Cross-references
Anatomy/cell type resources BTO; BTO_0002430
Encyclopedic resources Wikidata; Q54902422
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number15