ID   HA22T/VGH
AC   CVCL_7046
SY   Ha22T/VGH; HA 22T/VGH; HA22T
DR   BTO; BTO:0002429
DR   BCRC; 60168
DR   ChEMBL-Cells; CHEMBL3308657
DR   ChEMBL-Targets; CHEMBL614807
DR   Cosmic; 932991
DR   Cosmic; 934552
DR   Cosmic; 2668280
DR   PubChem_Cell_line; CVCL_7046
DR   Wikidata; Q54872284
RX   DOI=10.1007/978-4-431-68349-0_4;
RX   PubMed=2441881;
RX   PubMed=3023526;
RX   PubMed=3032404;
RX   PubMed=6291875;
RX   PubMed=6683778;
RX   PubMed=7972006;
RX   PubMed=8050184;
RX   PubMed=8224613;
RX   PubMed=29051253;
WW   http://www.abscience.com.tw/chinese/03product/01product_content.php?pid=2&tid=15&id=82
CC   Population: Chinese.
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg22Glyfs*14 (c.63_85del23); Zygosity=Unspecified (PubMed=7972006).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Mitochondrial genome sequenced.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): BCRC=60168
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 12
ST   D16S539: 11
ST   D5S818: 7,12
ST   D7S820: 11,12
ST   TH01: 7,9
ST   TPOX: 9,11
ST   vWA: 14,18
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
//
RX   DOI=10.1007/978-4-431-68349-0_4;
RA   Alexander J.J.;
RT   "Human hepatoma cell lines.";
RL   (In book chapter) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo; Japan (1987).
//
RX   PubMed=2441881; DOI=10.1016/0309-1651(87)90081-6;
RA   Lo S.-C.J., Yang C.-W., Hu C.-P., Chang C.-M.;
RT   "Absence of cytokeratin in human hepatoma cell lines.";
RL   Cell Biol. Int. Rep. 11:477-486(1987).
//
RX   PubMed=3023526; DOI=10.1099/0022-1317-67-11-2315;
RA   Aspinall S., Alexander J.J., Bos P.;
RT   "Comparative expression of hepatitis B virus antigens in several cell
RT   model systems.";
RL   J. Gen. Virol. 67:2315-2323(1986).
//
RX   PubMed=3032404; DOI=10.1016/0165-4608(87)90062-8;
RA   Wuu K.-D., Kang L., Su Y.-M., Wuu S.-W., Hu C.-P., Chang C.-M.;
RT   "Karyotypic characterization of an established human hepatoma cell
RT   line HA22T/VGH.";
RL   Cancer Genet. Cytogenet. 26:279-286(1987).
//
RX   PubMed=6291875;
RA   Lin Y.-M., Hu C.-P., Chou C.-K., O-Lee T.-W., Wuu K.-D., Chen T.-Y.,
RA   P'eng F.-K., Liu T.-J., Ko J.-L., Chang C.-M.;
RT   "A new human hepatoma cell line: establishment and characterization.";
RL   Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 15:193-201(1982).
//
RX   PubMed=6683778; DOI=10.1128/mcb.3.6.1133-1137.1983; PMCID=PMC368642;
RA   Chang C.-M., Lin Y.-M., O-Lee T.-W., Chou C.-K., Lee T.-S., Liu T.-J.,
RA   P'eng F.-K., Chen T.-Y., Hu C.-P.;
RT   "Induction of plasma protein secretion in a newly established human
RT   hepatoma cell line.";
RL   Mol. Cell. Biol. 3:1133-1137(1983).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=8050184; DOI=10.1111/j.1365-2249.1994.tb06089.x; PMCID=PMC1534706;
RA   Wadee A.A., Paterson A., Coplan K.A., Reddy S.G.;
RT   "HLA expression in hepatocellular carcinoma cell lines.";
RL   Clin. Exp. Immunol. 97:328-333(1994).
//
RX   PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613;
RA   Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E.,
RA   Ponchel F., Yakicier C., Ji J.-W., Ozturk M.;
RT   "Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell
RT   lines.";
RL   FASEB J. 7:1407-1413(1993).
//
RX   PubMed=29051253; DOI=10.1128/genomeA.01136-17; PMCID=PMC5646406;
RA   Huang D.-G., Cheng G., Wu J.-C.;
RT   "Complete mitochondrial genome of the human liver cancer HA22T cell
RT   line.";
RL   Genome Announc. 5:e01136.17.1-e01136.17.2(2017).
//